cis-2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)acrylonitrile

Base Information

Chemical Name:cis-2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)acrylonitrile
CAS No.:952196-28-0
Molecular Formula:C₂₄H₂₇BrN₂O₅
Molecular Weight:503.393
Hs Code.:

Synonyms:cis-2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)acrylonitrile

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Chemical Property of cis-2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)acrylonitrile

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Technology Process of cis-2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)acrylonitrile

There total 1 articles about cis-2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 5392-10-9
2-bromo-4,5-dimethoxybenzaldehyde

: 52590-27-9
N-methyl-N-(2-cyanomethyl-4,5-dimethoxyphenethyl)acetamide

: 952196-28-0
cis-2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)acrylonitrile

Guidance literature:: With sodium ethanolate; In ethanol; at 70 ℃;
DOI:10.1021/jo071038y

Reference yield: 84.0%

: 952196-28-0
cis-2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)acrylonitrile

: 952196-29-1
2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)propionitrile

Guidance literature:: With pyridine; sodium tetrahydroborate; In methanol; for 2h; Heating;
DOI:10.1021/jo071038y

Reference yield:

: 952196-28-0
cis-2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)acrylonitrile

: 952196-30-4
2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / NaBH₄; pyridine / methanol / 2 h / Heating

2: NaOH / H₂O; ethanol / 16 h / Heating

3: 1.98 g / Ac₂O / H₂O; ethanol / 1 h / 90 °C

With pyridine; sodium hydroxide; sodium tetrahydroborate; acetic anhydride; In methanol; ethanol; water;
DOI:10.1021/jo071038y