N-cyclopropyl-3-(2-(4-hydroxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

Base Information

Chemical Name:N-cyclopropyl-3-(2-(4-hydroxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide
CAS No.:1070293-27-4
Molecular Formula:C₂₇H₂₄N₂O₃
Molecular Weight:424.499
Hs Code.:

Synonyms:N-cyclopropyl-3-(2-(4-hydroxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

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Chemical Property of N-cyclopropyl-3-(2-(4-hydroxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

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Technology Process of N-cyclopropyl-3-(2-(4-hydroxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

There total 4 articles about N-cyclopropyl-3-(2-(4-hydroxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070292-75-9
N-cyclopropyl-4-methyl-3-(1-oxo-1,2-dihydroisoquinolin-6-yl)benzamide

: 39720-27-9
4-acetoxybenzyl chloride

: 1070293-27-4
N-cyclopropyl-3-(2-(4-hydroxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

Guidance literature:: N-cyclopropyl-4-methyl-3-(1-oxo-1,2-dihydroisoquinolin-6-yl)benzamide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4-acetoxybenzyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 19h;

With hydrogenchloride; sodium hydroxide; water; more than 3 stages;

Reference yield:

: 876189-18-3
[5-(methoxycarbonyl)-2-methylphenyl]boronic acid

: 1070293-27-4
N-cyclopropyl-3-(2-(4-hydroxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 95 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.17 h

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 19 h / 20 °C

With isopropylmagnesium chloride; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 82827-09-6
6-bromo-2H-isoquinoline-1-one

: 1070293-27-4
N-cyclopropyl-3-(2-(4-hydroxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 95 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.17 h

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 19 h / 20 °C

With isopropylmagnesium chloride; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;