4-(3,4-dimethyl-phenylsulfanyl)-thieno[2,3-c]pyridine-2-carboxylic acid

Base Information

• Chemical Name: 4-(3,4-dimethyl-phenylsulfanyl)-thieno[2,3-c]pyridine-2-carboxylic acid
• CAS No.: 1026811-03-9
• Molecular Formula: C₁₆H₁₃NO₂S₂
• Molecular Weight: 315.417

Synonyms:4-(3,4-dimethyl-phenylsulfanyl)-thieno[2,3-c]pyridine-2-carboxylic acid

Chemical Property of 4-(3,4-dimethyl-phenylsulfanyl)-thieno[2,3-c]pyridine-2-carboxylic acid

Chemical Property:

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Technology Process of 4-(3,4-dimethyl-phenylsulfanyl)-thieno[2,3-c]pyridine-2-carboxylic acid

There total 4 articles about 4-(3,4-dimethyl-phenylsulfanyl)-thieno[2,3-c]pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3,4-dimethyl-phenylsulfanyl)-thieno[2,3-c]pyridine-2-carboxylic acid methyl ester → 4-(3,4-dimethyl-phenylsulfanyl)-thieno[2,3-c]pyridine-2-carboxylic acid (1026811-03-9)

Guidance literature:

With lithium hydroxide; In isopropyl alcohol; at 75 ℃; for 1h;

DOI:10.1021/jm000452m

Reference yield:

3,5-dichloropyridine (2457-47-8) → 4-(3,4-dimethyl-phenylsulfanyl)-thieno[2,3-c]pyridine-2-carboxylic acid (1026811-03-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

1.2: 90 percent / tetrahydrofuran / 1.4 h / -78 °C

2.1: K₂CO₃ / dimethylformamide / 1.5 h / 0 - 20 °C

3.1: K₂CO₃ / dimethylformamide / 2 h / 60 °C

4.1: aq. LiOH / propan-2-ol / 1 h / 75 °C

With lithium hydroxide; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1021/jm000452m

Reference yield:

3,5-dichloropyridine-4-carboxaldehyde (136590-83-5) → 4-(3,4-dimethyl-phenylsulfanyl)-thieno[2,3-c]pyridine-2-carboxylic acid (1026811-03-9)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 1.5 h / 0 - 20 °C

2: K₂CO₃ / dimethylformamide / 2 h / 60 °C

3: aq. LiOH / propan-2-ol / 1 h / 75 °C

With lithium hydroxide; potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1021/jm000452m

upstream raw materials:

3,5-dichloropyridine

3,5-dichloropyridine-4-carboxaldehyde

3-chloro-5-(3,4-dimethyl-phenylsulfanyl)-pyridine-4-carbaldehyde

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