136590-83-5

Usage

Uses

Used in Organic Chemistry Research:
3,5-Dichloro-4-formyl pyridine is used as a key intermediate for the synthesis of various complex organic molecules. Its unique reactivity, due to the presence of the formyl group and chlorine atoms, allows for a wide range of chemical reactions, making it a valuable compound in the development of new organic compounds and materials.
Used in Pharmaceutical Industry:
3,5-Dichloro-4-formyl pyridine is used as a building block in the synthesis of pharmaceutical compounds. Its structural features enable it to be a versatile component in the creation of new drug molecules, potentially leading to the discovery of novel therapeutic agents.
Used in Material Science:
3,5-Dichloro-4-formyl pyridine is used as a precursor in the development of advanced materials. Its chemical properties can be exploited to create new materials with specific characteristics, such as improved stability or enhanced reactivity, which can be applied in various industries.

InChI:InChI=1/C6H3Cl2NO/c7-5-1-9-2-6(8)4(5)3-10/h1-3H

Upstream product

• 2457-47-8 3,5-dichloropyridine 
• 109-94-4 formic acid ethyl ester 
• 107-31-3 Methyl formate 
• 68-12-2 N,N-dimethyl-formamide 
• 109-72-8 n-butyllithium 
• 108-18-9 diisopropylamine 
• 159783-46-7 3,5-dichloro-4-hydroxymethylpyridine 
• 64-19-7 acetic acid 

Downstream Products

• 153463-65-1 3,5-dichloropyridine-4-carbonitrile 
• 1026026-67-4 3-chloro-5-cyclohexylsulfanyl-pyridine-4-carbaldehyde 
• 1027505-59-4 3-chloro-5-m-tolylsulfanyl-pyridine-4-carbaldehyde 
• 1026976-89-5 3-(biphenyl-4-ylsulfanyl)-5-chloro-pyridine-4-carbaldehyde 
• 1026845-35-1 3-chloro-5-(2,4-dimethyl-phenylsulfanyl)-pyridine-4-carbaldehyde 
• 1025910-29-5 3-chloro-5-(3,4-dimethyl-phenylsulfanyl)-pyridine-4-carbaldehyde 
• 1026940-66-8 3-chloro-5-(4-trifluoromethyl-phenylsulfanyl)-pyridine-4-carbaldehyde 
• 1027928-85-3 3-chloro-5-(3,5-dimethyl-phenylsulfanyl)-pyridine-4-carbaldehyde 
• 251996-85-7 methyl 4-chlorothieno[2,3-c]pyridine-2-carboxylate 
• 1027453-88-8 3-(4-bromo-phenylsulfanyl)-5-chloro-pyridine-4-carbaldehyde 
• 1026752-41-9 3-chloro-5-(4-chloro-phenylsulfanyl)-pyridine-4-carbaldehyde 
• 1025874-49-0 3-chloro-5-(4-chloro-benzylsulfanyl)-pyridine-4-carbaldehyde 
• 1025981-67-2 3-chloro-5-o-tolylsulfanyl-pyridine-4-carbaldehyde 
• 1026044-20-1 3,5-bis-p-tolyloxy-pyridine-4-carbaldehyde 

Relevant academic research and scientific papers

Towards redox-switchable organocatalysts based on bidentate halogen bond donors

Redox-active bidentate halogen bond donors based on halopyridinium groups as halogen-bond donating units were synthesized and their structures were elucidated by X-ray diffraction analyses and DFT calculations.Viareversible twofold reduction, these dicationic species can be transformed to neutral compounds which should be much weaker Lewis acids. The corresponding electrochemical data were obtained, and CV as well as UV-vis and NMR techniques were also used to determine binding constants of these halogen bond donors to halides. While all titrations agree on the relative order of binding strengths (with chloride being bound strongest), there are marked deviations in the overall affinity constants which are discussed. In contrast to earlier azo-bridge analogues, the ethylene-linked variants presented herein do not oxidize halides, and thus the novel halogen bond donors could also be used as Lewis acidic organocatalysts in a halide abstraction benchmark reaction, yielding a performance similar to bis(haloimidazolium)-derived catalysts.

An environmentally benign TEMPO-catalyzed efficient alcohol oxidation system with a recyclable hypervalent iodine(III) reagent and its facile preparation

A highly efficient 2,2,6,6-tetramethylpiperidin-1-yloxy (TEMPO) catalyzed alcohol oxidation system using recyclable 1-chloro-1,2-benziodoxol-3(1H)-one as the terminal oxidant in ethyl acetate, which is an environmentally friend organic solvent, at room temperature has been developed. A variety of alcohols can be oxidized to their corresponding carbonyl compounds in high to excellent yields. Various heteroaromatic rings and C=C bonds are well tolerated under the reaction conditions. 1-Chloro-1,2-benziodoxol-3(1H)-one can be easily recycled after simple solid/liquid-phase separation and the subsequent regeneration sequence. In addition, a safe, very convenient, large-scale, and high-yielding procedure for the preparation of 1-chloro-1,2-benziodoxol-3(1H)-one from 2-iodobenzoic acid has been developed using sodium chlorite as the stoichiometric oxidant in dilute hydrochloric acid at room temperature. Georg Thieme Verlag Stuttgart.

ANTAGONISTS OF THE MGLU RECEPTOR AND USES THEREOF

The present invention discloses compounds of general formula (I) wherein X1-X4 and R1-R3 are as defined in the description. The present invention also discloses methods of treatment for pain, neurodegeneration and convulsive states in a host mammal in need thereof, and pharmaceutical compositions including those compounds.

FUROISOQUINOLINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

A compound having a partial structure represented by Formula: or a salt thereof has an excellent phosphodiesterase (PDE) IV-inhibiting effect, and is useful as a prophylactic or therapeutic agent against inflammatory diseases, for example, bronchial asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, autoimmune disease, diabetes and the like.

Cell adhesion-inhibiting antiinflammatory compounds

Compounds having Formula I are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.

Aminopyrimidine derivatives, processes for their preparation, compositions containing them and their use as pharmaceuticals

There are provided novel compounds of formula (I) wherein: A represents a five membered heterocyclic aromatic ring containing 1 to 3 heteroatoms which may be the same or different and are selected from O, N and S; or a six membered heterocyclic aromatic r

Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression

A critical early event in the inflammatory cascade is the induced expression of cell adhesion molecules on the lumenal surface of vascular endothelial cells. These adhesion molecules include E-selectin, ICAM-1, and VCAM-1, which serve to recruit circulati

SUBSTITUTED VINYL PYRIDINE DERIVATIVE AND DRUGS CONTAINING THE SAME

The present invention relates to a substituted vinylpyridine derivative represented by the following formula (1): (wherein R1 represents a hydrogen atom, an alkyl group, etc., R2 represents an alkyl group; one of R3 and R4, which are different from each o

COMPOUNDS CONTAINING PHENYL LINKED TO ARYL OR HETEROARYL BY AN ALIPHATIC- OR HETEROATOM-CONTAINING LINKING GROUP

This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase

Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group

This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.