136590-83-5

Basic information

• Product Name: 3,5-DICHLORO-4-FORMYL PYRIDINE
• Synonyms: 3,5-Dichloropyridine-4-carboxaldehyde, 3,5-Dichloro-4-formylpyridine;3,5-Dichloro-4-pyridinecarboxaldehyde 97%;TIMTEC-BB SBB003785;3,5-DICHLORO-4-FORMYL PYRIDINE;3,5-DICHLOROISONICOTINALDEHYDE;3,5-DICHLORO-4-PYRIDINECARBOXALDEHYDE;3,5-DICHLOROPYRIDINE-4-CARBOXYALDEHYDE;3,5-Dichloropyridine-4-carboxaldehyde
• CAS NO: 136590-83-5
• Molecular Formula: C₆H₃Cl₂NO
• Molecular Weight: 176
• Product Categories: C5 to C6;C6 to C7;Carbonyl Compounds;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Organic Building Blocks;NULL;pharmacetical;Pyridine;Aldehyde;Organohalides;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridines;Aldehydes;Building Blocks;C1 to C6
• Mol File: 136590-83-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 75-79 °C(lit.)
• Boiling Point: 242.4 °C at 760 mmHg
• Flash Point: 100.4 °C
• Appearance: /
• Density: 1.488 g/cm³
• Vapor Pressure: 0.0341mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: -0.42±0.10(Predicted)
• CAS DataBase Reference: 3,5-DICHLORO-4-FORMYL PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DICHLORO-4-FORMYL PYRIDINE(136590-83-5)
• EPA Substance Registry System: 3,5-DICHLORO-4-FORMYL PYRIDINE(136590-83-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 136590-83-5(Hazardous Substances Data)

Usage

General Description

3,5-Dichloro-4-formyl pyridine is an organic compound primarily used in the field of organic chemistry. This chemical consists of a pyridine ring, which is a basic aromatic six-member ring with five carbon atoms and a nitrogen atom. The other distinctive features of this chemical are the presence of two chlorine atoms, positioned on the 3rd and 5th carbon atoms, and a formyl group located at the 4th carbon of the pyridine ring. Due to the functional group, it exhibits unique reactivity properties, making it useful for various synthetic approaches. As with all chemicals, safety precautions should be taken while handling it due to potential risks and hazards.

InChI:InChI=1/C6H3Cl2NO/c7-5-1-9-2-6(8)4(5)3-10/h1-3H

Upstream product

• 2457-47-8 3,5-dichloropyridine 
• 109-94-4 formic acid ethyl ester 
• 159783-46-7 3,5-dichloro-4-hydroxymethylpyridine 
• 64-19-7 acetic acid 
• 107-31-3 Methyl formate 
• 108-18-9 diisopropylamine 
• 109-72-8 n-butyllithium 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1027928-85-3 3-chloro-5-(3,5-dimethyl-phenylsulfanyl)-pyridine-4-carbaldehyde 
• 1026752-41-9 3-chloro-5-(4-chloro-phenylsulfanyl)-pyridine-4-carbaldehyde 
• 1025981-67-2 3-chloro-5-o-tolylsulfanyl-pyridine-4-carbaldehyde 
• 1026044-20-1 3,5-bis-p-tolyloxy-pyridine-4-carbaldehyde 
• 1027411-21-7 3,5-bis-(3-trifluoromethyl-phenoxy)-pyridine-4-carbaldehyde 
• 1027553-42-9 3,5-bis-(4-{1-[2-(2-ethoxy-ethoxy)-ethoxymethyl]-cyclopropyl}-phenoxy)-pyridine-4-carbaldehyde 
• 2457-47-8 3,5-dichloropyridine 
• 251996-49-3 [4-(5-chloro-4-formylpyridin-3-yloxy)phenyl]carbamic acid tert-butyl ester 
• 1025805-96-2 3,5-bis-(4-chloro-phenoxy)-pyridine-4-carbaldehyde 

Relevant articles and documents

Towards redox-switchable organocatalysts based on bidentate halogen bond donors

Redox-active bidentate halogen bond donors based on halopyridinium groups as halogen-bond donating units were synthesized and their structures were elucidated by X-ray diffraction analyses and DFT calculations.Viareversible twofold reduction, these dicationic species can be transformed to neutral compounds which should be much weaker Lewis acids. The corresponding electrochemical data were obtained, and CV as well as UV-vis and NMR techniques were also used to determine binding constants of these halogen bond donors to halides. While all titrations agree on the relative order of binding strengths (with chloride being bound strongest), there are marked deviations in the overall affinity constants which are discussed. In contrast to earlier azo-bridge analogues, the ethylene-linked variants presented herein do not oxidize halides, and thus the novel halogen bond donors could also be used as Lewis acidic organocatalysts in a halide abstraction benchmark reaction, yielding a performance similar to bis(haloimidazolium)-derived catalysts.

ANTAGONISTS OF THE MGLU RECEPTOR AND USES THEREOF

The present invention discloses compounds of general formula (I) wherein X1-X4 and R1-R3 are as defined in the description. The present invention also discloses methods of treatment for pain, neurodegeneration and convulsive states in a host mammal in need thereof, and pharmaceutical compositions including those compounds.

Cell adhesion-inhibiting antiinflammatory compounds

Compounds having Formula I are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.