(S)-2-({2-[3-(2-chloro-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid

Base Information

Chemical Name:(S)-2-({2-[3-(2-chloro-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid
CAS No.:1400704-48-4
Molecular Formula:C₂₄H₂₆ClN₅O₅S
Molecular Weight:532.02
Hs Code.:

Synonyms:(S)-2-({2-[3-(2-chloro-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid

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Chemical Property of (S)-2-({2-[3-(2-chloro-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid

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Technology Process of (S)-2-({2-[3-(2-chloro-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid

There total 12 articles about (S)-2-({2-[3-(2-chloro-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₈ClN₅O₅S

: 1400704-48-4
(S)-2-({2-[3-(2-chloro-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid

Guidance literature:: C₂₅H₂₈ClN₅O₅S; With lithium hydroxide monohydrate; water; In methanol; at 20 ℃; for 2h;

With potassium hydrogensulfate; In tetrahydrofuran; water; pH=2 - 4;

Reference yield:

: 89694-46-2
2-chloro-5-methoxyphenylboronic acid

: 1400704-48-4
(S)-2-({2-[3-(2-chloro-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium iodide; chloroamine-T / water; methanol / 0.25 h / 20 °C / flask wrapped with aluminum foil

2.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere; sealed vessel

2.2: 18 h / 20 °C

3.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / 30003 Torr / H-Cube

4.1: boron tribromide / dichloromethane / 2 h / 0 - 20 °C

4.2: Cooling with ice

5.1: water; lithium hydroxide monohydrate / methanol / 2 h / 20 °C

5.2: pH 2 - 4

With lithium hydroxide monohydrate; water; hydrogen; chloroamine-T; boron tribromide; triethylamine; sodium iodide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 5%-palladium/activated carbon; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 2401-25-4
1-chloro-2-iodo-4-methoxybenzene

: 1400704-48-4
(S)-2-({2-[3-(2-chloro-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere; sealed vessel

1.2: 18 h / 20 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / 30003 Torr / H-Cube

3.1: boron tribromide / dichloromethane / 2 h / 0 - 20 °C

3.2: Cooling with ice

4.1: water; lithium hydroxide monohydrate / methanol / 2 h / 20 °C

4.2: pH 2 - 4

With lithium hydroxide monohydrate; water; hydrogen; boron tribromide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 5%-palladium/activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;