N-(trans-4-trifluoromethyl-cyclohexyl)-6-methylamino-5-amino-2-(4-trifluoromethyl-piperidinyl)-nicotinic acid amide

Base Information

Chemical Name:N-(trans-4-trifluoromethyl-cyclohexyl)-6-methylamino-5-amino-2-(4-trifluoromethyl-piperidinyl)-nicotinic acid amide
CAS No.:1380648-49-6
Molecular Formula:C₂₀H₂₇F₆N₅O
Molecular Weight:467.458
Hs Code.:

Synonyms:N-(trans-4-trifluoromethyl-cyclohexyl)-6-methylamino-5-amino-2-(4-trifluoromethyl-piperidinyl)-nicotinic acid amide

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Chemical Property of N-(trans-4-trifluoromethyl-cyclohexyl)-6-methylamino-5-amino-2-(4-trifluoromethyl-piperidinyl)-nicotinic acid amide

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Technology Process of N-(trans-4-trifluoromethyl-cyclohexyl)-6-methylamino-5-amino-2-(4-trifluoromethyl-piperidinyl)-nicotinic acid amide

There total 4 articles about N-(trans-4-trifluoromethyl-cyclohexyl)-6-methylamino-5-amino-2-(4-trifluoromethyl-piperidinyl)-nicotinic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1380648-47-4
N-(trans-4-trifluoromethyl-cyclohexyl)-6-methylamino-5-nitro-2-(4-trifluoromethyl-piperidinyl)-nicotinic acid amide

: 1380648-49-6
N-(trans-4-trifluoromethyl-cyclohexyl)-6-methylamino-5-amino-2-(4-trifluoromethyl-piperidinyl)-nicotinic acid amide

Guidance literature:: With hydrogen; Ra-Ni; In tetrahydrofuran; for 4h; under 2585.81 Torr;

Reference yield:

: 657-36-3
4-Trifluormethyl-piperidin

: 1380648-49-6
N-(trans-4-trifluoromethyl-cyclohexyl)-6-methylamino-5-amino-2-(4-trifluoromethyl-piperidinyl)-nicotinic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide; acetonitrile / 3 h / 20 °C

1.2: 20 - 70 °C

2.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h

2.2: 0.5 h

3.1: hydrogen / Ra-Ni / tetrahydrofuran / 4 h / 2585.81 Torr

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; Ra-Ni; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1218944-66-1
2-(2,2-difluoro-ethoxy)-6-methylamino-5-nitro-nicotinic acid

: 1380648-49-6
N-(trans-4-trifluoromethyl-cyclohexyl)-6-methylamino-5-amino-2-(4-trifluoromethyl-piperidinyl)-nicotinic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide; acetonitrile / 3 h / 20 °C

1.2: 20 - 70 °C

2.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h

2.2: 0.5 h

3.1: hydrogen / Ra-Ni / tetrahydrofuran / 4 h / 2585.81 Torr

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; Ra-Ni; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;