C₃₂H₃₀F₆N₄O₄

Base Information

• Chemical Name: C₃₂H₃₀F₆N₄O₄
• CAS No.: 1601475-81-3
• Molecular Formula: C₃₂H₃₀F₆N₄O₄
• Molecular Weight: 648.605
• Mol file: 1601475-81-3.mol

Synonyms:C₃₂H₃₀F₆N₄O₄

Chemical Property of C₃₂H₃₀F₆N₄O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₃₀F₆N₄O₄

There total 11 articles about C₃₂H₃₀F₆N₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,3S,5S)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-formic acid ethyl ester (214193-11-0) → C32H30F6N4O4 (1601475-81-3)

Guidance literature:

Multi-step reaction with 11 steps

1: hydrogenchloride; water

2: N,N-dimethyl-formamide

3: lithium aluminium tetrahydride

4: trifluoroacetic anhydride; triethylamine

5: hydrogen; hydrogenchloride; palladium 10% on activated carbon / diethyl ether; water

6: sodium hydroxide / tetrahydrofuran

7: Dess-Martin periodane

8: 0 - 40 °C

9: HATU; N-ethyl-N,N-diisopropylamine

10: hydrogenchloride; water / 1,4-dioxane

11: HATU

With hydrogenchloride; lithium aluminium tetrahydride; palladium 10% on activated carbon; water; hydrogen; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic anhydride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; N,N-dimethyl-formamide; 8: |Bargellini Reaction;

DOI:10.1016/j.bmcl.2014.02.055

Reference yield:

C11H17NO3 → C32H30F6N4O4 (1601475-81-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 0 - 40 °C

2: HATU; N-ethyl-N,N-diisopropylamine

3: hydrogenchloride; water / 1,4-dioxane

4: HATU

With hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; 1: |Bargellini Reaction;

DOI:10.1016/j.bmcl.2014.02.055

Reference yield:

C19H22F3NO5 → C32H30F6N4O4 (1601475-81-3)

Guidance literature:

Multi-step reaction with 3 steps

1: HATU; N-ethyl-N,N-diisopropylamine

2: hydrogenchloride; water / 1,4-dioxane

3: HATU

With hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2014.02.055

upstream raw materials:

4-(trifluoromethyl)nicotinic acid

(1S,3S,5S)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-formic acid ethyl ester

C₈H₁₃NO₂

C₁₃H₁₇NO