2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 2-(1,1-dimethylethyl) 3-ethyl ester, (1S,3S,5S)-

Base Information

Chemical Name:2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 2-(1,1-dimethylethyl) 3-ethyl ester, (1S,3S,5S)-
CAS No.:214193-11-0
Molecular Formula:C13H21NO4
Molecular Weight:255.314
Hs Code.:
Mol file:214193-11-0.mol

Synonyms:N-Boc-L-cis-4,5-methanoproline ethyl ester;(1S,3S,5S)-2-TERT-BUTYL 3-ETHYL 2-AZABICYCLO[3.1.0]HEXANE-2,3-DICARBOXYLATE;(1S,3S,5S)-2-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-tert-butyl ester 3-ethyl ester;(s)-BOC-4,5-methanoproline ethyl ester;

Suppliers and Price of 2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 2-(1,1-dimethylethyl) 3-ethyl ester, (1S,3S,5S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylicAcid2-(1,1-Dimethylethyl)3-ethylEster
1g
$ 1025.00

Matrix Scientific
(1S,3S,5S)-2-tert-Butyl 3-ethyl 2-azabicyclo[3.1.0]hexane-2,3-dicarboxylate 95%
1g
$ 1110.00

Matrix Scientific
(1S,3S,5S)-2-tert-Butyl 3-ethyl 2-azabicyclo[3.1.0]hexane-2,3-dicarboxylate 95%
5g
$ 2036.00

Crysdot
(1S,3S,5S)-2-tert-Butyl3-ethyl2-azabicyclo[3.1.0]hexane-2,3-dicarboxylate 95+%
1g
$ 1568.00

American Custom Chemicals Corporation
2-TERT-BUTYL-3-ETHYL (1S,3S,5S)-2-AZABICYCLO[3.1.0]HEXANE-2,3-DICARBOXYLATE 95.00%
10G
$ 2428.53

American Custom Chemicals Corporation
2-TERT-BUTYL-3-ETHYL (1S,3S,5S)-2-AZABICYCLO[3.1.0]HEXANE-2,3-DICARBOXYLATE 95.00%
5G
$ 1535.95

American Custom Chemicals Corporation
2-TERT-BUTYL-3-ETHYL (1S,3S,5S)-2-AZABICYCLO[3.1.0]HEXANE-2,3-DICARBOXYLATE 95.00%
1G
$ 659.93

Total 34 raw suppliers

Chemical Property of 2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 2-(1,1-dimethylethyl) 3-ethyl ester, (1S,3S,5S)-

Chemical Property:

Boiling Point:321.7±25.0 °C(Predicted)
PKA:-2.71±0.40(Predicted)
PSA：55.84000
Density:1.161±0.06 g/cm3(Predicted)
LogP:1.88530

Purity/Quality:

99%, ^*data from raw suppliers

(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylicAcid2-(1,1-Dimethylethyl)3-ethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic Acid 2-(1,1-Dimethylethyl) 3-ethyl Ester acts as a reagent for the preparation of captopril analogs as inhibitors of angiotensin converting enzyme. Core modification of substituted piperidines as novel inhibitors of HDM2-p53 protein-protein interaction.

Technology Process of 2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 2-(1,1-dimethylethyl) 3-ethyl ester, (1S,3S,5S)-

There total 15 articles about 2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 2-(1,1-dimethylethyl) 3-ethyl ester, (1S,3S,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: BOC-4,5-methanoproline ethyl ester

: 214193-11-0
(1S,3S,5S)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-formic acid ethyl ester

Guidance literature:: With methylamine; In water; at 20 - 25 ℃;

Reference yield: 50.0%

: 593-71-5
Chloroiodomethane

: 178172-26-4
(5S)-4,5-dihydro-1H-pyrrol-1,5-dicarboxylic acid [1-(1,1-dimethylethyl)] 5-ethyl ester

: 214193-11-0
(1S,3S,5S)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-formic acid ethyl ester

Guidance literature:: With diethylzinc; In 1,2-dichloro-ethane; at -15 ℃; for 19h;

Reference yield: 32.5%

: 178172-26-4
(5S)-4,5-dihydro-1H-pyrrol-1,5-dicarboxylic acid [1-(1,1-dimethylethyl)] 5-ethyl ester

: 74-95-3
1,1-dibromomethane

: 214193-11-0
(1S,3S,5S)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-formic acid ethyl ester

Guidance literature:: With trifluoroacetic acid; copper(I) bromide; zinc; In tetrahydrofuran; at 25 - 50 ℃; for 18h; Temperature; Solvent; Reagent/catalyst; Catalytic behavior; Inert atmosphere;