5-Bromo-2-fluoro-4-methyl-pyridine

Base Information

• Chemical Name: 5-Bromo-2-fluoro-4-methyl-pyridine
• CAS No.: 864830-16-0
• Molecular Formula: C6H5 Br F N
• Molecular Weight: 190.015
• Hs Code.: 2933399090
• Mol file: 864830-16-0.mol

Synonyms:5-Bromo-2-fluoro-4-methyl-pyridine

Chemical Property of 5-Bromo-2-fluoro-4-methyl-pyridine

Chemical Property:

• Vapor Pressure: 0.301mmHg at 25°C
• Refractive Index: 1.5300
• Boiling Point: 208.9oC at 760 mmHg
• PKA: -2.13±0.18(Predicted)
• Flash Point: 80.2oC
• PSA: 12.89000
• Density: 1.592g/cm3
• LogP: 2.29160
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-2-fluoro-4-methylpyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T,Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Bromo-2-fluoro-4-methylpyridine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

Technology Process of 5-Bromo-2-fluoro-4-methyl-pyridine

There total 2 articles about 5-Bromo-2-fluoro-4-methyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-5-bromo-4-methylpyridine (98198-48-2) → 5-bromo-2-fluoro-4-methyl-pyridine (864830-16-0)

Guidance literature:

2-amino-5-bromo-4-methylpyridine; With nitrosonium tetrafluoroborate; In chloroform; at 0 - 20 ℃; for 2h;

In dimethyl sulfoxide; at 150 ℃;

Reference yield:

2-Amino-4-methylpyridine (695-34-1) → 5-bromo-2-fluoro-4-methyl-pyridine (864830-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridinium hydrobromide perbromide / tetrahydrofuran / 2.17 h / 20 °C

2.1: nitrosonium tetrafluoroborate / chloroform / 2 h / 0 - 20 °C

2.2: 150 °C

With pyridinium hydrobromide perbromide; nitrosonium tetrafluoroborate; In tetrahydrofuran; chloroform;

Reference yield: 96.0%

5-bromo-2-fluoro-4-methyl-pyridine (864830-16-0) + phenylmethanethiol (100-53-8) → 2-(benzylthio)-5-bromo-4-methylpyridine

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 12h;

upstream raw materials:

2-amino-5-bromo-4-methylpyridine

2-Amino-4-methylpyridine

Downstream raw materials:

4-(5-bromo-4-methylpyridin-2-yl)morpholine

5-bromo-2-methoxy-4-methylpyridine