N-(4-(3-cyclopropyl-5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)pyridin-2-yl)acetamide

Base Information

• Chemical Name: N-(4-(3-cyclopropyl-5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)pyridin-2-yl)acetamide
• CAS No.: 1258077-84-7
• Molecular Formula: C₁₉H₁₇FN₄OS
• Molecular Weight: 368.435

Synonyms:N-(4-(3-cyclopropyl-5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)pyridin-2-yl)acetamide

Chemical Property of N-(4-(3-cyclopropyl-5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)pyridin-2-yl)acetamide

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Technology Process of N-(4-(3-cyclopropyl-5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)pyridin-2-yl)acetamide

There total 2 articles about N-(4-(3-cyclopropyl-5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)pyridin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H17FN4O2 (1258077-75-6) → N-(4-(3-cyclopropyl-5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)pyridin-2-yl)acetamide (1258077-84-7)

Guidance literature:

With 2,2,4,4-tetramethylcyclobutane-1,3-dithione; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2010.09.012

Reference yield:

(E)-N-(4-(2-(4-fluorophenyl)-2-(hydroxyimino)acetyl)pyridin-2-yl)acetamide → N-(4-(3-cyclopropyl-5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)pyridin-2-yl)acetamide (1258077-84-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 80 °C

2: 2,2,4,4-tetramethylcyclobutane-1,3-dithione / dichloromethane / 2 h / 20 °C

With 2,2,4,4-tetramethylcyclobutane-1,3-dithione; In ethanol; dichloromethane;

DOI:10.1021/jm501557a

Reference yield: 74.0%

ethyl (E)-3-iodopropenoate (31930-36-6,31930-37-7) + N-(4-(3-cyclopropyl-5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)pyridin-2-yl)acetamide (1258077-84-7) → ethyl (E)-3-((5-(2-acetamidopyridin-4-yl)-1-cyclopropyl-4-(4-fluorophenyl)-1H-imidazol-2-yl)thio)acrylate

Guidance literature:

ethyl (E)-3-iodopropenoate; With 1,4-diaza-bicyclo[2.2.2]octane; In N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

N-(4-(3-cyclopropyl-5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)pyridin-2-yl)acetamide; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm501557a

upstream raw materials:

C₁₉H₁₇FN₄O₂

Downstream raw materials:

C₂₀H₁₉FN₄OS

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