2,5-DIBROMO-3-FLUOROPYRIDINE

Base Information

• Chemical Name: 2,5-DIBROMO-3-FLUOROPYRIDINE
• CAS No.: 156772-60-0
• Molecular Formula: C5H2Br2FN
• Molecular Weight: 254.88
• Hs Code.: 2933399990
• Mol file: 156772-60-0.mol

Synonyms:3-Fluoro-2,5-dibromopyridine;

Chemical Property of 2,5-DIBROMO-3-FLUOROPYRIDINE

Chemical Property:

• Vapor Pressure: 0.212mmHg at 25°C
• Refractive Index: 1.58
• Boiling Point: 215.9 °C at 760 mmHg
• PKA: -3.99±0.20(Predicted)
• Flash Point: 84.4 °C
• PSA: 12.89000
• Density: 2.137 g/cm³
• LogP: 2.74570
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2,5-Dibromo-3-fluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,5-Dibromo-3-fluoropyridine can be used as PRC2 inhibitors to treat cancer.

Technology Process of 2,5-DIBROMO-3-FLUOROPYRIDINE

There total 5 articles about 2,5-DIBROMO-3-FLUOROPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.4%

3-bromo-5-fluoro-1-oxidopyridin-1-ium → 2,5-dibromo-3-fluoropyridine (156772-60-0)

Guidance literature:

With Oxalyl bromide; triethylamine; at -60 ℃; for 0.5h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01057

Reference yield: 51.0%

C5H2Br2N3(1+)*F(1-) → 2,5-dibromo-3-fluoropyridine (156772-60-0)

Guidance literature:

C₅H₂Br₂N₃⁽¹⁺⁾*F^(1-); In Petroleum ether; at 90 ℃;

With sodium carbonate; In water; Petroleum ether; at 20 ℃;

Reference yield: 51.0%

C5H2Br2N3(1+)*Cl(1-) → 2,5-dibromo-3-fluoropyridine (156772-60-0)

Guidance literature:

With Petroleum ether; at 90 ℃;

upstream raw materials:

2,5-dibromopyridin-3-ylamine

Downstream raw materials:

5-bromo-3-fluoro-2-methylpyridine

5-bromo-3-fluoro-2-(4-octyloxyphenyl)pyridine

1-(5-bromo-3-fluoropyridin-2-yl)ethan-1-one