5-BROMO-3-FLUORO-2-METHYLPYRIDINE

Base Information

• Chemical Name: 5-BROMO-3-FLUORO-2-METHYLPYRIDINE
• CAS No.: 1162674-74-9
• Molecular Formula: C₆H₅BrFN
• Molecular Weight: 190.015
• Hs Code.: 2933399990
• Mol file: 1162674-74-9.mol

Synonyms:5-BROMO-3-FLUORO-2-METHYLPYRIDINE

Chemical Property of 5-BROMO-3-FLUORO-2-METHYLPYRIDINE

Chemical Property:

• Boiling Point: 168.3±35.0 °C(Predicted)
• PKA: 1.17±0.20(Predicted)
• PSA: 12.89000
• Density: 1.592±0.06 g/cm3(Predicted)
• LogP: 2.29160
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

5-Bromo-3-fluoro-2-methylpyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-3-FLUORO-2-METHYLPYRIDINE

There total 2 articles about 5-BROMO-3-FLUORO-2-METHYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

5-bromo-2-methylpyridin-3-ylamine (914358-73-9) → 5-bromo-3-fluoro-2-methylpyridine (1162674-74-9)

Guidance literature:

With nitrosonium tetrafluoroborate; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

2,5-dibromo-3-fluoropyridine (156772-60-0) + dihydroxy-methyl-borane (13061-96-6) → 5-bromo-3-fluoro-2-methylpyridine (1162674-74-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; toluene; at 60 ℃; for 168h;

upstream raw materials:

5-bromo-2-methylpyridin-3-ylamine

2,5-dibromo-3-fluoropyridine

dihydroxy-methyl-borane