t-butyl [6-(imidazo[1,2-d][1,2,4]thiadiazol-3-yl(methyl)amino)butyl][(2-nitrophenyl)sulfonyl]carbamate

Base Information

Chemical Name:t-butyl [6-(imidazo[1,2-d][1,2,4]thiadiazol-3-yl(methyl)amino)butyl][(2-nitrophenyl)sulfonyl]carbamate
CAS No.:863983-34-0
Molecular Formula:C₂₀H₂₆N₆O₆S₂
Molecular Weight:510.595
Hs Code.:

Synonyms:t-butyl [6-(imidazo[1,2-d][1,2,4]thiadiazol-3-yl(methyl)amino)butyl][(2-nitrophenyl)sulfonyl]carbamate

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Chemical Property of t-butyl [6-(imidazo[1,2-d][1,2,4]thiadiazol-3-yl(methyl)amino)butyl][(2-nitrophenyl)sulfonyl]carbamate

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Technology Process of t-butyl [6-(imidazo[1,2-d][1,2,4]thiadiazol-3-yl(methyl)amino)butyl][(2-nitrophenyl)sulfonyl]carbamate

There total 4 articles about t-butyl [6-(imidazo[1,2-d][1,2,4]thiadiazol-3-yl(methyl)amino)butyl][(2-nitrophenyl)sulfonyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 863983-33-9
t-butyl [6-(imidazo[1,2-d][1,2,4]thiadiazol-3-ylamino)butyl][(2-nitrophenyl)sulfonyl]carbamate

: 74-88-4
methyl iodide

: 863983-34-0
t-butyl [6-(imidazo[1,2-d][1,2,4]thiadiazol-3-yl(methyl)amino)butyl][(2-nitrophenyl)sulfonyl]carbamate

Guidance literature:: With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1021/jo0507486

Reference yield:

: 863983-23-7
N-[6-(imidazo[1,2-d][1,2,4]thiadiazol-3-ylamino)butyl]-2-nitrobenzenesulfonamide

: 863983-34-0
t-butyl [6-(imidazo[1,2-d][1,2,4]thiadiazol-3-yl(methyl)amino)butyl][(2-nitrophenyl)sulfonyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / DMAP / acetonitrile / 16 h / 20 °C

2: 88 percent / potassium carbonate; KOH; n-Bu₄NSO₄H / CH₂Cl₂ / 15 h / 20 °C

With dmap; potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In dichloromethane; acetonitrile;
DOI:10.1021/jo0507486

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 863983-34-0
t-butyl [6-(imidazo[1,2-d][1,2,4]thiadiazol-3-yl(methyl)amino)butyl][(2-nitrophenyl)sulfonyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / triethylamine / CH₂Cl₂ / 20 °C

2: 65 percent / triethylamine / dimethylformamide

3: 86 percent / DMAP / acetonitrile / 16 h / 20 °C

4: 88 percent / potassium carbonate; KOH; n-Bu₄NSO₄H / CH₂Cl₂ / 15 h / 20 °C

With dmap; potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo0507486