(2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)methyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

Base Information

Chemical Name:(2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)methyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine
CAS No.:156480-55-6
Molecular Formula:C₂₂H₂₇NO₄
Molecular Weight:369.461
Hs Code.:

Synonyms:(2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)methyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)methyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

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Technology Process of (2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)methyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

There total 4 articles about (2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)methyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 156365-81-0
(2S,4S,5R)-4-methyl-2-(1-oxo-1-phenyl)methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

: 156480-55-6
(2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)methyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

Guidance literature:: With sodium tetrahydroborate; cerium(III) chloride; In methanol; for 1.5h; Ambient temperature;
DOI:10.1016/0040-4020(95)00145-X

Reference yield:

: 100-52-7
benzaldehyde

: 156480-55-6
(2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)methyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C

2: pyridinium dichromate / dimethylformamide

3: NaBH₄, LiI

With sodium tetrahydroborate; dipyridinium dichromate; n-butyllithium; lithium iodide; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)73050-4

Reference yield:

: (2S,4S,5R)-4-Methyl-5-phenyl-2-tributylstannanyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 156480-55-6
(2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)methyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C

2: pyridinium dichromate / dimethylformamide

3: NaBH₄, LiI

With sodium tetrahydroborate; dipyridinium dichromate; n-butyllithium; lithium iodide; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)73050-4