3,4-(2,2-dibenzylpropane-1,3-diyldioxy)-2,5-bis(hydroxyphenylmethyl)thiophene

Base Information

Chemical Name:3,4-(2,2-dibenzylpropane-1,3-diyldioxy)-2,5-bis(hydroxyphenylmethyl)thiophene
CAS No.:738625-79-1
Molecular Formula:C₃₅H₃₂O₄S
Molecular Weight:548.703
Hs Code.:

Synonyms:3,4-(2,2-dibenzylpropane-1,3-diyldioxy)-2,5-bis(hydroxyphenylmethyl)thiophene

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Chemical Property of 3,4-(2,2-dibenzylpropane-1,3-diyldioxy)-2,5-bis(hydroxyphenylmethyl)thiophene

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Technology Process of 3,4-(2,2-dibenzylpropane-1,3-diyldioxy)-2,5-bis(hydroxyphenylmethyl)thiophene

There total 4 articles about 3,4-(2,2-dibenzylpropane-1,3-diyldioxy)-2,5-bis(hydroxyphenylmethyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 100-52-7
benzaldehyde

: 406940-42-9
3,3-dibenzyl-3,4-dihydro-2H-thienopheno[3,4-b][1,4]dioxepine

: (3,3-dibenzyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepin-6-yl)-phenyl-methanol

: 738625-79-1
3,4-(2,2-dibenzylpropane-1,3-diyldioxy)-2,5-bis(hydroxyphenylmethyl)thiophene

Guidance literature:: 3,3-dibenzyl-3,4-dihydro-2H-thienopheno[3,4-b][1,4]dioxepine; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In hexane; for 1h; Heating;

benzaldehyde; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1246/bcsj.77.1173

Reference yield:

: 100-44-7
benzyl chloride

: 738625-79-1
3,4-(2,2-dibenzylpropane-1,3-diyldioxy)-2,5-bis(hydroxyphenylmethyl)thiophene

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaOH / ethanol / Heating

1.2: 60 percent / ethanol / Heating

2.1: 74 percent / LiAlH₄ / tetrahydrofuran

3.1: 67 percent / TsOH / toluene / 35 h / 80 °C

4.1: BuLi; TMEDA / hexane / 1 h / Heating

4.2: 17 percent / tetrahydrofuran / 1 h / 0 °C

With sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; hexane; toluene;
DOI:10.1246/bcsj.77.1173

Reference yield:

: 31952-16-6
2,2-dibenzyl-1,3-propanediol

: 738625-79-1
3,4-(2,2-dibenzylpropane-1,3-diyldioxy)-2,5-bis(hydroxyphenylmethyl)thiophene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 67 percent / TsOH / toluene / 35 h / 80 °C

2.1: BuLi; TMEDA / hexane / 1 h / Heating

2.2: 17 percent / tetrahydrofuran / 1 h / 0 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; toluene-4-sulfonic acid; In hexane; toluene;
DOI:10.1246/bcsj.77.1173