ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetate

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Chemical Name:ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetate
CAS No.:1370706-20-9
Molecular Formula:C₂₉H₂₈FN₃O₅
Molecular Weight:517.557
Hs Code.:

Synonyms:ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetate

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Chemical Property of ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetate

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Technology Process of ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetate

There total 4 articles about ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1370706-03-8
4-((7-((4-fluorobenzyl)amino)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzonitrile

: 4755-77-5
Ethyl oxalyl chloride

: 1370706-20-9
ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2012.01.059

Reference yield:

: 847671-40-3
ethyl 2,4-dimethyl-7-nitro-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylate

: 1370706-20-9
ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetate

Guidance literature:: Multi-step reaction with 6 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 4 h / Reflux

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 48 h / Reflux

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C

4: methanol / 5 h / 20 °C / Inert atmosphere; Molecular sieve

5: sodium tetrahydroborate / methanol / 2 h / 20 °C

6: triethylamine / dichloromethane / 2 h / 20 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; dimethylsulfide borane complex; palladium 10% on activated carbon; hydrogen; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1016/j.ejmech.2012.01.059

Reference yield:

: 1056737-05-3
(2,4-dimethyl-7-nitro-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methanol

: 1370706-20-9
ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(4-fluorobenzyl)amino)-2-oxoacetate

Guidance literature:: Multi-step reaction with 5 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 48 h / Reflux

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C

3: methanol / 5 h / 20 °C / Inert atmosphere; Molecular sieve

4: sodium tetrahydroborate / methanol / 2 h / 20 °C

5: triethylamine / dichloromethane / 2 h / 20 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1016/j.ejmech.2012.01.059