N-[8-Bromo-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide

Base Information

• Chemical Name: N-[8-Bromo-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide
• CAS No.: 129451-78-1
• Molecular Formula: C₁₇H₁₆BrN₅O₄
• Molecular Weight: 434.249

Synonyms:N-[8-Bromo-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide

Chemical Property of N-[8-Bromo-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide

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Technology Process of N-[8-Bromo-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide

There total 1 articles about N-[8-Bromo-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzoyl chloride (98-88-4) + 8-bromo-2'-deoxyadenosine (14985-44-5,90968-89-1) → N-[8-Bromo-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide (129451-78-1)

Guidance literature:

With pyridine; chloro-trimethyl-silane;

DOI:10.1016/S0040-4020(01)89916-6

Reference yield:

N-[8-Bromo-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide (129451-78-1) → N-{9-{5-[2,2-bis-(4-methoxy-phenyl)-2-phenyl-ethyl]-4-hydroxy-tetrahydro-furan-2-yl}-8-[2-(3H-imidazol-4-yl)-ethylamino]-9H-purin-6-yl}-benzamide

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: ethanol

With pyridine; In ethanol;

DOI:10.1021/ja0205075

Reference yield:

N-[8-Bromo-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide (129451-78-1) → (8-(2-(4-imidazolyl)ethylamino))-5'-DMT-2'deoxyribouridine-3'-diisopropyl-β-cyanoethoxyphosphoramidite

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine

2: ethanol

3: ethyldiisopropylamine

With pyridine; N-ethyl-N,N-diisopropylamine; In ethanol;

DOI:10.1021/ja0205075

upstream raw materials:

benzoyl chloride

8-bromo-2'-deoxyadenosine

Downstream raw materials:

N-(9-{5-[bis(4-methoxyphenyl)phenylmethoxyphenyl]-4-hydroxytetrahydrofuran-2-yl}-8-bromo-9H-purin-6-yl)benzamide

C₆₀H₆₁ClN₉O₁₅P

3'-O-acetyl-N⁶-benzoyl-8-amino(2-N-acetylaminoethyl)-2'-deoxyadenosine

3'-O-acetyl-N⁶-benzoyl-8-(1-N-acetylhistamino)-2'-deoxyadenosine

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