(S)-7-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxymethyl)-heptanenitrile

Base Information

Chemical Name:(S)-7-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxymethyl)-heptanenitrile
CAS No.:131702-88-0
Molecular Formula:C₂₁H₃₅NO₂Si
Molecular Weight:361.6
Hs Code.:

Synonyms:(S)-7-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxymethyl)-heptanenitrile

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Chemical Property of (S)-7-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxymethyl)-heptanenitrile

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Technology Process of (S)-7-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxymethyl)-heptanenitrile

There total 8 articles about (S)-7-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxymethyl)-heptanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2049-80-1
(2-propenyl)propanedioic acid diethyl ester

: 131702-88-0
(S)-7-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxymethyl)-heptanenitrile

Guidance literature:: Multi-step reaction with 8 steps

1: 1) tert-BuOK, 2) HCl / 1) tert.-butanol, 1 h, r.t.

2: 100 percent / aq. KOH / ethanol / 48 h / Ambient temperature

3: 70 percent / 150 °C / 1 - 2 Torr

5: 1) CH₂N₂, 2) LiCl, NaBH₄ / 1) ether, 2) EtOH, 50 deg C, 10 h

6: 76 percent / imidazole / CH₂Cl₂ / 24 h / Ambient temperature

7: 1) 9-BBN, 2) H₂O₂, aq. NaOH / 1) THF, 1.5 h, r.t., 2) 1 h, r.t.

8: 1) tert-BuOK / 1) THF, 5 min, r.t., 2) 10 h, r.t.

With diazomethane; 1H-imidazole; hydrogenchloride; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; 9-borabicyclo[3.3.1]nonane dimer; potassium tert-butylate; dihydrogen peroxide; lithium chloride; In ethanol; dichloromethane;
DOI:10.1021/jo00003a038

Reference yield:

: 131702-77-7
4-(hydroxymethyl)-6-heptenenitrile

: 131702-88-0
(S)-7-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxymethyl)-heptanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / imidazole / CH₂Cl₂ / 24 h / Ambient temperature

2: 1) 9-BBN, 2) H₂O₂, aq. NaOH / 1) THF, 1.5 h, r.t., 2) 1 h, r.t.

3: 1) tert-BuOK / 1) THF, 5 min, r.t., 2) 10 h, r.t.

With 1H-imidazole; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; potassium tert-butylate; dihydrogen peroxide; In dichloromethane;
DOI:10.1021/jo00003a038

Reference yield:

: 131702-86-8
1,3-diethyl 2-allyl-2-(2-cyanoethyl)malonate

: 131702-88-0
(S)-7-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxymethyl)-heptanenitrile

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / aq. KOH / ethanol / 48 h / Ambient temperature

2: 70 percent / 150 °C / 1 - 2 Torr

4: 1) CH₂N₂, 2) LiCl, NaBH₄ / 1) ether, 2) EtOH, 50 deg C, 10 h

5: 76 percent / imidazole / CH₂Cl₂ / 24 h / Ambient temperature

6: 1) 9-BBN, 2) H₂O₂, aq. NaOH / 1) THF, 1.5 h, r.t., 2) 1 h, r.t.

7: 1) tert-BuOK / 1) THF, 5 min, r.t., 2) 10 h, r.t.

With diazomethane; 1H-imidazole; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; 9-borabicyclo[3.3.1]nonane dimer; potassium tert-butylate; dihydrogen peroxide; lithium chloride; In ethanol; dichloromethane;
DOI:10.1021/jo00003a038