(R)-5-(3-Benzyloxy-propyl)-tetrahydro-pyran-2-one

Base Information

Chemical Name:(R)-5-(3-Benzyloxy-propyl)-tetrahydro-pyran-2-one
CAS No.:131726-97-1
Molecular Formula:C₁₅H₂₀O₃
Molecular Weight:248.322
Hs Code.:

Synonyms:

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Chemical Property of (R)-5-(3-Benzyloxy-propyl)-tetrahydro-pyran-2-one

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Technology Process of (R)-5-(3-Benzyloxy-propyl)-tetrahydro-pyran-2-one

There total 11 articles about (R)-5-(3-Benzyloxy-propyl)-tetrahydro-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2049-80-1
(2-propenyl)propanedioic acid diethyl ester

: 131726-97-1
(R)-5-(3-Benzyloxy-propyl)-tetrahydro-pyran-2-one

Guidance literature:: Multi-step reaction with 10 steps

1: 1) tert-BuOK, 2) HCl / 1) tert.-butanol, 1 h, r.t.

2: 100 percent / aq. KOH / ethanol / 48 h / Ambient temperature

3: 70 percent / 150 °C / 1 - 2 Torr

5: 1) CH₂N₂, 2) LiCl, NaBH₄ / 1) ether, 2) EtOH, 50 deg C, 10 h

6: 76 percent / imidazole / CH₂Cl₂ / 24 h / Ambient temperature

7: 1) 9-BBN, 2) H₂O₂, aq. NaOH / 1) THF, 1.5 h, r.t., 2) 1 h, r.t.

8: 1) tert-BuOK / 1) THF, 5 min, r.t., 2) 10 h, r.t.

9: 87 percent / H₂SO₄ / dioxane / Ambient temperature

10: 1) aq. KOH, 2) p-toluenesulfonic acid / 1) EtOH, 50 deg C, 8 h, 2) benzene, reflux, 30 min

With diazomethane; 1H-imidazole; hydrogenchloride; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; 9-borabicyclo[3.3.1]nonane dimer; sulfuric acid; potassium tert-butylate; dihydrogen peroxide; toluene-4-sulfonic acid; lithium chloride; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/jo00003a038

Reference yield:

: 100-39-0
benzyl bromide

: 131726-97-1
(R)-5-(3-Benzyloxy-propyl)-tetrahydro-pyran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1) tert-BuOK / 1) THF, 5 min, r.t., 2) 10 h, r.t.

2: 87 percent / H₂SO₄ / dioxane / Ambient temperature

3: 1) aq. KOH, 2) p-toluenesulfonic acid / 1) EtOH, 50 deg C, 8 h, 2) benzene, reflux, 30 min

With potassium hydroxide; sulfuric acid; potassium tert-butylate; toluene-4-sulfonic acid; In 1,4-dioxane;
DOI:10.1021/jo00003a038

Reference yield:

: 131702-77-7
4-(hydroxymethyl)-6-heptenenitrile

: 131726-97-1
(R)-5-(3-Benzyloxy-propyl)-tetrahydro-pyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / imidazole / CH₂Cl₂ / 24 h / Ambient temperature

2: 1) 9-BBN, 2) H₂O₂, aq. NaOH / 1) THF, 1.5 h, r.t., 2) 1 h, r.t.

3: 1) tert-BuOK / 1) THF, 5 min, r.t., 2) 10 h, r.t.

4: 87 percent / H₂SO₄ / dioxane / Ambient temperature

5: 1) aq. KOH, 2) p-toluenesulfonic acid / 1) EtOH, 50 deg C, 8 h, 2) benzene, reflux, 30 min

With 1H-imidazole; potassium hydroxide; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; sulfuric acid; potassium tert-butylate; dihydrogen peroxide; toluene-4-sulfonic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jo00003a038