5-((((2S,3S,5R)-3-((tert-butyldiphenylsilyl)oxy)-5-((S)-2,2,9,9,10,10-hexamethyl-3,3-diphenyl-4,8-dioxa-3,9-disilaundecan-5-yl)tetrahydrofuran-2-yl)methyl)thio)-1-phenyl-1H-tetrazole

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Chemical Name:5-((((2S,3S,5R)-3-((tert-butyldiphenylsilyl)oxy)-5-((S)-2,2,9,9,10,10-hexamethyl-3,3-diphenyl-4,8-dioxa-3,9-disilaundecan-5-yl)tetrahydrofuran-2-yl)methyl)thio)-1-phenyl-1H-tetrazole
CAS No.:1434154-18-3
Molecular Formula:C₅₃H₇₀N₄O₆SSi₃
Molecular Weight:975.484
Hs Code.:

5-((((2S,3S,5R)-3-((tert-butyldiphenylsilyl)oxy)-5-((S)-2,2,9,9,10,10-hexamethyl-3,3-diphenyl-4,8-dioxa-3,9-disilaundecan-5-yl)tetrahydrofuran-2-yl)methyl)thio)-1-phenyl-1H-tetrazole

Synonyms:5-((((2S,3S,5R)-3-((tert-butyldiphenylsilyl)oxy)-5-((S)-2,2,9,9,10,10-hexamethyl-3,3-diphenyl-4,8-dioxa-3,9-disilaundecan-5-yl)tetrahydrofuran-2-yl)methyl)thio)-1-phenyl-1H-tetrazole

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Chemical Property of 5-((((2S,3S,5R)-3-((tert-butyldiphenylsilyl)oxy)-5-((S)-2,2,9,9,10,10-hexamethyl-3,3-diphenyl-4,8-dioxa-3,9-disilaundecan-5-yl)tetrahydrofuran-2-yl)methyl)thio)-1-phenyl-1H-tetrazole

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Technology Process of 5-((((2S,3S,5R)-3-((tert-butyldiphenylsilyl)oxy)-5-((S)-2,2,9,9,10,10-hexamethyl-3,3-diphenyl-4,8-dioxa-3,9-disilaundecan-5-yl)tetrahydrofuran-2-yl)methyl)thio)-1-phenyl-1H-tetrazole

There total 11 articles about 5-((((2S,3S,5R)-3-((tert-butyldiphenylsilyl)oxy)-5-((S)-2,2,9,9,10,10-hexamethyl-3,3-diphenyl-4,8-dioxa-3,9-disilaundecan-5-yl)tetrahydrofuran-2-yl)methyl)thio)-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1434154-66-1
C₅₃H₇₀N₄O₄SSi₃

: 1434154-18-3
5-((((2S,3S,5R)-3-((tert-butyldiphenylsilyl)oxy)-5-((S)-2,2,9,9,10,10-hexamethyl-3,3-diphenyl-4,8-dioxa-3,9-disilaundecan-5-yl)tetrahydrofuran-2-yl)methyl)thio)-1-phenyl-1H-tetrazole

Guidance literature:: C₅₃H₇₀N₄O₄SSi₃; With ammonium molybdate; dihydrogen peroxide; In isopropyl alcohol; at 20 ℃;

With 1H-imidazole; tert-butyldimethylsilyl chloride; In dichloromethane; isopropyl alcohol; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo4004647

Reference yield:

: 1434154-59-2
C₂₅H₃₂O₃Si

: 1434154-18-3
5-((((2S,3S,5R)-3-((tert-butyldiphenylsilyl)oxy)-5-((S)-2,2,9,9,10,10-hexamethyl-3,3-diphenyl-4,8-dioxa-3,9-disilaundecan-5-yl)tetrahydrofuran-2-yl)methyl)thio)-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 8 steps

1.1: titanium(IV) isopropylate; diethyl (2S,3S)-tartrate; tert.-butylhydroperoxide / dichloromethane; decane / 0.33 h / 20 °C / Inert atmosphere; Molecular sieve

1.2: -20 °C / Inert atmosphere

2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / 1 h / -30 - 0 °C / Inert atmosphere

3.1: 1H-imidazole / dichloromethane / 20 °C / Inert atmosphere

4.1: 1H-imidazole / 20 °C

5.1: ozone; oxygen / dichloromethane; methanol / -78 °C

5.2: 1 h / -78 - 20 °C

6.1: sodium tetrahydroborate / methanol / 1 h / 0 °C

7.1: triphenylphosphine; diethylazodicarboxylate / toluene / 3 h / 20 °C / Inert atmosphere

8.1: ammonium molybdate; dihydrogen peroxide / isopropyl alcohol / 20 °C

8.2: 2 h / 20 °C / Inert atmosphere

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium tetrahydroborate; ammonium molybdate; diethyl (2S,3S)-tartrate; dihydrogen peroxide; oxygen; ozone; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; diethylazodicarboxylate; In tetrahydrofuran; methanol; decane; dichloromethane; isopropyl alcohol; toluene; 1.1: |Sharpless Asymmetric Epoxidation / 7.1: |Mitsunobu Displacement;
DOI:10.1021/jo4004647

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1434154-18-3
5-((((2S,3S,5R)-3-((tert-butyldiphenylsilyl)oxy)-5-((S)-2,2,9,9,10,10-hexamethyl-3,3-diphenyl-4,8-dioxa-3,9-disilaundecan-5-yl)tetrahydrofuran-2-yl)methyl)thio)-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 10 steps

1.1: 1H-imidazole / dichloromethane / 6 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / methanol / 20 h / 20 °C

3.1: titanium(IV) isopropylate; diethyl (2S,3S)-tartrate; tert.-butylhydroperoxide / dichloromethane; decane / 0.33 h / 20 °C / Inert atmosphere; Molecular sieve

3.2: -20 °C / Inert atmosphere

4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / 1 h / -30 - 0 °C / Inert atmosphere

5.1: 1H-imidazole / dichloromethane / 20 °C / Inert atmosphere

6.1: 1H-imidazole / 20 °C

7.1: ozone; oxygen / dichloromethane; methanol / -78 °C

7.2: 1 h / -78 - 20 °C

8.1: sodium tetrahydroborate / methanol / 1 h / 0 °C

9.1: triphenylphosphine; diethylazodicarboxylate / toluene / 3 h / 20 °C / Inert atmosphere

10.1: ammonium molybdate; dihydrogen peroxide / isopropyl alcohol / 20 °C

10.2: 2 h / 20 °C / Inert atmosphere

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium tetrahydroborate; ammonium molybdate; diethyl (2S,3S)-tartrate; dihydrogen peroxide; oxygen; potassium carbonate; ozone; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; diethylazodicarboxylate; In tetrahydrofuran; methanol; decane; dichloromethane; isopropyl alcohol; toluene; 3.1: |Sharpless Asymmetric Epoxidation / 9.1: |Mitsunobu Displacement;
DOI:10.1021/jo4004647