tetrahydrofuran-3-carboxylic acid {2-methyl-5-[5-(3,4.5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3ylmethyl}amide

Base Information

Chemical Name:tetrahydrofuran-3-carboxylic acid {2-methyl-5-[5-(3,4.5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3ylmethyl}amide
CAS No.:1398110-63-8
Molecular Formula:C₂₁H₁₈Cl₃F₃N₂O₄
Molecular Weight:525.739
Hs Code.:

Synonyms:tetrahydrofuran-3-carboxylic acid {2-methyl-5-[5-(3,4.5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3ylmethyl}amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tetrahydrofuran-3-carboxylic acid {2-methyl-5-[5-(3,4.5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3ylmethyl}amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tetrahydrofuran-3-carboxylic acid {2-methyl-5-[5-(3,4.5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3ylmethyl}amide

There total 10 articles about tetrahydrofuran-3-carboxylic acid {2-methyl-5-[5-(3,4.5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3ylmethyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89364-31-8
3-tetrahydrofuroic acid

: 1398110-65-0
C-{2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-yl}methylamine

: 1398110-63-8
tetrahydrofuran-3-carboxylic acid {2-methyl-5-[5-(3,4.5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3ylmethyl}amide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 21928-51-8
5-bromo-1,2,3-trichloro-benzene

: 1398110-63-8
tetrahydrofuran-3-carboxylic acid {2-methyl-5-[5-(3,4.5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3ylmethyl}amide

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-butyllithium / dichloromethane / 1.25 h / -78 °C / Inert atmosphere

2.1: lithium hydride / tert-butyl methyl ether; tetrahydrofuran / 1.5 h / 0 - 60 °C

3.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 0.5 h / 20 °C

4.1: hydroxylamine hydrochloride; cesiumhydroxide monohydrate / dichloromethane / 1.5 h / 0 - 20 °C

5.1: diisobutylaluminium hydride / toluene; diethyl ether / 20 h / -5 - 20 °C / Inert atmosphere

6.1: manganese(IV) oxide / dichloromethane / 18 h / 20 °C

7.1: trifluoroacetic acid; triethylsilane / acetonitrile / 20 h / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

8.2: pH 12

9.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 24 h / 20 °C

With triethylsilane; manganese(IV) oxide; n-butyllithium; cesiumhydroxide monohydrate; hydroxylamine hydrochloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; lithium hydride; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; diethyl ether; dichloromethane; tert-butyl methyl ether; toluene; acetonitrile;

Reference yield:

: 158401-00-4
1-(3,4,5-trichloro-phenyl)-2,2,2-trifluoro-ethanone

: 1398110-63-8
tetrahydrofuran-3-carboxylic acid {2-methyl-5-[5-(3,4.5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3ylmethyl}amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hydride / tert-butyl methyl ether; tetrahydrofuran / 1.5 h / 0 - 60 °C

2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 0.5 h / 20 °C

3.1: hydroxylamine hydrochloride; cesiumhydroxide monohydrate / dichloromethane / 1.5 h / 0 - 20 °C

4.1: diisobutylaluminium hydride / toluene; diethyl ether / 20 h / -5 - 20 °C / Inert atmosphere

5.1: manganese(IV) oxide / dichloromethane / 18 h / 20 °C

6.1: trifluoroacetic acid; triethylsilane / acetonitrile / 20 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

7.2: pH 12

8.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 24 h / 20 °C

With triethylsilane; manganese(IV) oxide; cesiumhydroxide monohydrate; hydroxylamine hydrochloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; lithium hydride; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; diethyl ether; dichloromethane; tert-butyl methyl ether; toluene; acetonitrile;