(1R,2R,3S,4R)-3-<(4''-methoxyphenyl)methyl>-1,7,7-trimethylbicyclo<2.2.1>hept-2-ol

Base Information

Chemical Name:(1R,2R,3S,4R)-3-<(4''-methoxyphenyl)methyl>-1,7,7-trimethylbicyclo<2.2.1>hept-2-ol
CAS No.:147514-14-5
Molecular Formula:C₁₈H₂₆O₂
Molecular Weight:274.403
Hs Code.:

Synonyms:(1R,2R,3S,4R)-3-<(4''-methoxyphenyl)methyl>-1,7,7-trimethylbicyclo<2.2.1>hept-2-ol

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Chemical Property of (1R,2R,3S,4R)-3-<(4''-methoxyphenyl)methyl>-1,7,7-trimethylbicyclo<2.2.1>hept-2-ol

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Technology Process of (1R,2R,3S,4R)-3-<(4''-methoxyphenyl)methyl>-1,7,7-trimethylbicyclo<2.2.1>hept-2-ol

There total 5 articles about (1R,2R,3S,4R)-3-<(4''-methoxyphenyl)methyl>-1,7,7-trimethylbicyclo<2.2.1>hept-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 74-96-4
ethyl bromide

: 141340-28-5
(1R,2R,3S,4R)-3-[(4-methoxyphenyl)methyl]-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl propanoate

: 147514-14-5
(1R,2R,3S,4R)-3-<(4''-methoxyphenyl)methyl>-1,7,7-trimethylbicyclo<2.2.1>hept-2-ol

: 2-methylbutanoic acid (1R,2R,3S,4R)-3-[(4-methoxyphenyl)methyl]-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester

: (1R,2R,3S,4R)-3-[(4-methoxyphenyl)methyl]-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl 2-ethyl-2-methylbutanoate

: 2-methyl-3-oxopentanoic acid (1R,2R,3S,4R)-3-[(4-methoxyphenyl)methyl]-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester

Guidance literature:: (1R,2R,3S,4R)-3-[(4-methoxyphenyl)methyl]-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl propanoate; With lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; at -78 ℃; for 2h;

ethyl bromide; In tetrahydrofuran; cyclohexane; at -78 - 20 ℃; for 24h;
DOI:10.1055/s-2002-33115

Reference yield:

: 147514-17-8
(1R,2R,3S,4R)-3-<(4''-methoxyphenyl)methyl>-1,7,7-trimethylbicyclo<2.2.1>hept-2-yl 4-nitrobenzoate

: 147514-14-5
(1R,2R,3S,4R)-3-<(4''-methoxyphenyl)methyl>-1,7,7-trimethylbicyclo<2.2.1>hept-2-ol

Guidance literature:: With potassium hydroxide; In ethanol; water; for 2h; Heating;
DOI:10.1080/00397919308020396

Reference yield:

: 464-49-3,68546-28-1
(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one

: 147514-14-5
(1R,2R,3S,4R)-3-<(4''-methoxyphenyl)methyl>-1,7,7-trimethylbicyclo<2.2.1>hept-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, RT, 18 h

2: 1.) Na, 2.) pyridine / 1.) EtOH, reflux, 20 min, 2.) RT

3: KOH / ethanol; H₂O / 2 h / Heating

With pyridine; potassium hydroxide; sodium; lithium diisopropyl amide; In ethanol; water;
DOI:10.1080/00397919308020396