2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(methylsulfonyl-methyl)quinazolin-4-amine

Base Information

Chemical Name:2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(methylsulfonyl-methyl)quinazolin-4-amine
CAS No.:1241915-81-0
Molecular Formula:C₂₁H₁₈F₃N₅O₂S
Molecular Weight:461.467
Hs Code.:

Synonyms:2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(methylsulfonyl-methyl)quinazolin-4-amine

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Chemical Property of 2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(methylsulfonyl-methyl)quinazolin-4-amine

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Technology Process of 2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(methylsulfonyl-methyl)quinazolin-4-amine

There total 6 articles about 2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(methylsulfonyl-methyl)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.5%

: 1241915-76-3
(2-(difluoro(4-fluorophenyl)methyl)-4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-7-yl)-methanol

: 5188-07-8
sodium thiomethoxide

: 1241915-81-0
2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(methylsulfonyl-methyl)quinazolin-4-amine

Guidance literature:: (2-(difluoro(4-fluorophenyl)methyl)-4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-7-yl)-methanol; With phosphorus tribromide; In dichloromethane; at 60 ℃; for 0.5h;

sodium thiomethoxide; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: sodium thiomethoxide

: 937-22-4
p-chloroperbenzoic acid

: 1241915-76-3
(2-(difluoro(4-fluorophenyl)methyl)-4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-7-yl)-methanol

: 1241915-81-0
2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(methylsulfonyl-methyl)quinazolin-4-amine

Guidance literature:: With phosphorus tribromide; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide;

Reference yield:

: 1241915-77-4
methyl 4-carbamoyl-3-(2,2-difluoro-2-(4-fluorophenyl)acetamido)benzoate

: 1241915-81-0
2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(methylsulfonyl-methyl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: chloro-trimethyl-silane; triethylamine / methanol

2: trichlorophosphate / toluene; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

3: DIEA; Ki / N,N-dimethyl-formamide

4: lithium aluminium tetrahydride; NaOH / water; tetrahydrofuran

5: phosphorus tribromide / N,N-dimethyl-formamide; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

With lithium aluminium tetrahydride; NaOH; chloro-trimethyl-silane; Ki; DIEA; phosphorus tribromide; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide; toluene;