4-{5-[(3R,4R)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-yl]-[1,2,4]oxadiazol-3-ylmethoxy}piperidine-1-carboxylic acid isopropyl ester

Base Information

Chemical Name:4-{5-[(3R,4R)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-yl]-[1,2,4]oxadiazol-3-ylmethoxy}piperidine-1-carboxylic acid isopropyl ester
CAS No.:1245079-63-3
Molecular Formula:C₃₃H₄₂F₂N₆O₆
Molecular Weight:656.73
Hs Code.:

4-{5-[(3R,4R)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-yl]-[1,2,4]oxadiazol-3-ylmethoxy}piperidine-1-carboxylic acid isopropyl ester

Synonyms:4-{5-[(3R,4R)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-yl]-[1,2,4]oxadiazol-3-ylmethoxy}piperidine-1-carboxylic acid isopropyl ester

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Chemical Property of 4-{5-[(3R,4R)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-yl]-[1,2,4]oxadiazol-3-ylmethoxy}piperidine-1-carboxylic acid isopropyl ester

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Technology Process of 4-{5-[(3R,4R)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-yl]-[1,2,4]oxadiazol-3-ylmethoxy}piperidine-1-carboxylic acid isopropyl ester

There total 1 articles about 4-{5-[(3R,4R)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-yl]-[1,2,4]oxadiazol-3-ylmethoxy}piperidine-1-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1245078-67-4
[(3R,4R)-4-(2,5-difluorophenyl)piperidin-3-yl]carbamic acid tert-butyl ester

: 1245078-53-8
4-[5-(6-chloropyridin-3-yl)-[1,2,4]oxadiazol-3-ylmethoxy]piperidine-1-carboxylic acid isopropyl ester

: 1245079-63-3
4-{5-[(3R,4R)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-yl]-[1,2,4]oxadiazol-3-ylmethoxy}piperidine-1-carboxylic acid isopropyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tert-butyl alcohol; at 80 ℃;

Reference yield:

: 1245079-63-3
4-{5-[(3R,4R)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-yl]-[1,2,4]oxadiazol-3-ylmethoxy}piperidine-1-carboxylic acid isopropyl ester

: 1245077-85-3
4-{5-[(3R,4R)-3-amino-4-(2,5-difluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-yl]-[1,2,4]oxadiazol-3-ylmethoxy}piperidine-1-carboxylic acid isopropyl ester hydrochloride

Guidance literature:: 4-{5-[(3R,4R)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-yl]-[1,2,4]oxadiazol-3-ylmethoxy}piperidine-1-carboxylic acid isopropyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With ammonium hydroxide; In methanol;

With hydrogenchloride; In 1,4-dioxane;