[(3R,4R)-4-(2,5-difluorophenyl)piperidin-3-yl]carbamic acid tert-butyl ester

Base Information

Chemical Name:[(3R,4R)-4-(2,5-difluorophenyl)piperidin-3-yl]carbamic acid tert-butyl ester
CAS No.:1245078-67-4
Molecular Formula:C₁₆H₂₂F₂N₂O₂
Molecular Weight:312.36
Hs Code.:

Synonyms:[(3R,4R)-4-(2,5-difluorophenyl)piperidin-3-yl]carbamic acid tert-butyl ester

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Chemical Property of [(3R,4R)-4-(2,5-difluorophenyl)piperidin-3-yl]carbamic acid tert-butyl ester

Chemical Property:

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Technology Process of [(3R,4R)-4-(2,5-difluorophenyl)piperidin-3-yl]carbamic acid tert-butyl ester

There total 5 articles about [(3R,4R)-4-(2,5-difluorophenyl)piperidin-3-yl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1245078-65-2
[(3R,4R)-1-benzyl-4-(2,5-difluorophenyl)piperidin-3-yl]carbamic acid tert-butyl ester

: 1245078-67-4
[(3R,4R)-4-(2,5-difluorophenyl)piperidin-3-yl]carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 80 ℃; under 22502.3 Torr;

Reference yield:

: 1245078-62-9
3-(2,5-difluorophenyl)-4-nitrobutyric acid methyl ester

: 1245078-67-4
[(3R,4R)-4-(2,5-difluorophenyl)piperidin-3-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 16 h / 90 °C / sealed tube

2.1: dimethylsulfide borane complex / dichloromethane; tetrahydrofuran / 3 h / 70 °C / Inert atmosphere

2.2: 20 °C

3.1: zinc; acetic acid / ethanol / 80 °C

4.1: triethylamine / water; tetrahydrofuran / 16 h / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 80 °C / 22502.3 Torr

With dimethylsulfide borane complex; hydrogen; acetic acid; triethylamine; zinc; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;

Reference yield:

: C₁₈H₂₀F₂N₂*(x)ClH

: 1245078-67-4
[(3R,4R)-4-(2,5-difluorophenyl)piperidin-3-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / water; tetrahydrofuran / 16 h / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 80 °C / 22502.3 Torr

With hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water;