2-(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)indan-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2-(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)indan-2-carboxylic acid ethyl ester
• CAS No.: 907185-71-1
• Molecular Formula: C₂₅H₃₆N₂O₅
• Molecular Weight: 444.571
• Mol file: 907185-71-1.mol

Synonyms:2-(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)indan-2-carboxylic acid ethyl ester

Chemical Property of 2-(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)indan-2-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)indan-2-carboxylic acid ethyl ester

There total 1 articles about 2-(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)indan-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate (141104-65-6) + (2R)-[(tert-butoxycarbonyl)-amino](cyclohexyl)ethanoic acid (70491-05-3) → 2-(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)indan-2-carboxylic acid ethyl ester (907185-71-1)

Guidance literature:

With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm0606950

Reference yield: 95.0%

2-(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)indan-2-carboxylic acid ethyl ester (907185-71-1) → 2-(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)-indan-2-carboxylic acid (907185-93-7)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 80 ℃; for 4h;

DOI:10.1021/jm0606950

Reference yield:

2-(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)indan-2-carboxylic acid ethyl ester (907185-71-1) → {[4-({[2-(R)-(2-amino-2-cyclohexyl-acetylamino)indane-2-carbonyl]-amino}-methyl)-phenyl]-imino-methyl}-carbamic acid benzyl ester dihydrochloride

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / aq. NaOH / dioxane / 4 h / 80 °C

2: 84 percent / diisopropylethylamine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 20 °C

3: 95 percent / HCl(gas) / ethyl acetate / 2 h / 20 °C

With hydrogenchloride; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm0606950

upstream raw materials:

ethyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate

(2R)-[(tert-butoxycarbonyl)-amino](cyclohexyl)ethanoic acid

Downstream raw materials:

2-(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)-indan-2-carboxylic acid

({2-(R)-[4-(benzyloxycarbonylamino-imino-methyl)benzylcarbamoyl]-indan-2-ylcarbamoyl}-cyclohexyl-methyl)-carbamic acid tert-butyl ester