3'-O-acetyl-5'-dideuterated 2'-C-methyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate

Base Information

Chemical Name:3'-O-acetyl-5'-dideuterated 2'-C-methyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate
CAS No.:1365634-64-5
Molecular Formula:C₂₄H₃₂N₃O₁₀PS
Molecular Weight:587.556
Hs Code.:

Synonyms:3'-O-acetyl-5'-dideuterated 2'-C-methyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate

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Chemical Property of 3'-O-acetyl-5'-dideuterated 2'-C-methyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate

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Technology Process of 3'-O-acetyl-5'-dideuterated 2'-C-methyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate

There total 5 articles about 3'-O-acetyl-5'-dideuterated 2'-C-methyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1365634-63-4
5'-dideuterated 2'-C-methyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate

: 108-24-7
acetic anhydride

: 1365634-64-5
3'-O-acetyl-5'-dideuterated 2'-C-methyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate

Guidance literature:: With pyridine; at 35 ℃; for 16h;

Reference yield:

: 944476-45-3
1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2,3a-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4(1H,3H)-dione

: 1365634-64-5
3'-O-acetyl-5'-dideuterated 2'-C-methyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic anhydride; dipyridinium dichromate / dichloromethane / 3 h / 20 °C

2.1: sodium borodeuteride / 80 °C

2.2: 0 °C

3.1: trifluoroacetic acid; water / 0.5 h / 0 - 20 °C

4.1: 1-methyl-1H-imidazole / acetonitrile / 24 h / 20 °C

5.1: pyridine / 16 h / 35 °C

With pyridine; 1-methyl-1H-imidazole; dipyridinium dichromate; sodium borodeuteride; water; acetic anhydride; trifluoroacetic acid; In dichloromethane; acetonitrile;

Reference yield:

: 1365634-60-1
C₁₇H₂₄N₂O₇

: 1365634-64-5
3'-O-acetyl-5'-dideuterated 2'-C-methyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium borodeuteride / 80 °C

1.2: 0 °C

2.1: trifluoroacetic acid; water / 0.5 h / 0 - 20 °C

3.1: 1-methyl-1H-imidazole / acetonitrile / 24 h / 20 °C

4.1: pyridine / 16 h / 35 °C

With pyridine; 1-methyl-1H-imidazole; sodium borodeuteride; water; trifluoroacetic acid; In acetonitrile;