tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-(dimethylcarbamoyl)phenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Base Information

Chemical Name:tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-(dimethylcarbamoyl)phenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate
CAS No.:1400286-98-7
Molecular Formula:C₂₉H₃₄N₆O₅
Molecular Weight:546.626
Hs Code.:

Synonyms:tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-(dimethylcarbamoyl)phenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

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Chemical Property of tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-(dimethylcarbamoyl)phenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

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Technology Process of tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-(dimethylcarbamoyl)phenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

There total 10 articles about tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-(dimethylcarbamoyl)phenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400286-67-0
tert-butyl-2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-chloro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

: 6331-71-1
4-amino-N,N-dimethylbenzamide

: 1400286-98-7
tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-(dimethylcarbamoyl)phenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In water; tert-butyl alcohol; at 80 ℃; for 3.33333h; Microwave irradiation;

Reference yield:

: 14432-12-3
4-Amino-2-chloropyridine

: 1400286-98-7
tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-(dimethylcarbamoyl)phenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium acetate; Iodine monochloride / acetic acid / 3.5 h / 70 °C

2: triethylamine / dichloromethane / 17.67 h / 20 °C / Cooling with ice

3: sodium hydroxide / tetrahydrofuran

4: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 60 °C / Microwave irradiation

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 3.25 h / 100 °C / Microwave irradiation

6: triethylamine / dmap / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

7: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / water; tert-butyl alcohol / 3.33 h / 80 °C / Microwave irradiation

With potassium phosphate; sodium acetate; Iodine monochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; dmap; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tert-butyl XPhos; In tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

: 800402-12-4
2-chloro-4-amino-5-iodopyridine

: 1400286-98-7
tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-(dimethylcarbamoyl)phenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 17.67 h / 20 °C / Cooling with ice

2: sodium hydroxide / tetrahydrofuran

3: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 60 °C / Microwave irradiation

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 3.25 h / 100 °C / Microwave irradiation

5: triethylamine / dmap / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

6: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / water; tert-butyl alcohol / 3.33 h / 80 °C / Microwave irradiation

With potassium phosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; dmap; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tert-butyl XPhos; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;