N-(α-methylbenzyl)-N-hydroxysuccinamic acid

Base Information

• Chemical Name: N-(α-methylbenzyl)-N-hydroxysuccinamic acid
• CAS No.: 172101-72-3
• Molecular Formula: C₁₂H₁₅NO₄
• Molecular Weight: 237.255
• Mol file: 172101-72-3.mol

Synonyms:N-(α-methylbenzyl)-N-hydroxysuccinamic acid

Chemical Property of N-(α-methylbenzyl)-N-hydroxysuccinamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of N-(α-methylbenzyl)-N-hydroxysuccinamic acid

There total 1 articles about N-(α-methylbenzyl)-N-hydroxysuccinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

succinic acid anhydride (108-30-5) + N-(1-phenyl-ethyl)-hydroxylamine (2912-98-3,53933-47-4,67377-55-3,101314-62-9) → N-(α-methylbenzyl)-N-hydroxysuccinamic acid (172101-72-3)

Guidance literature:

In tetrahydrofuran; for 16h; Heating;

DOI:10.1016/0040-4020(95)00737-S

Reference yield: 43.0%

N-(α-methylbenzyl)-N-hydroxysuccinamic acid (172101-72-3) → N-(α-methylbenzyl)tetrahydro-1,2-oxazine-3,6-dione (101067-46-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; at 0 ℃; for 1h;

DOI:10.1016/0040-4020(95)00737-S

Reference yield:

N-(α-methylbenzyl)-N-hydroxysuccinamic acid (172101-72-3) → (+/-)-1-(α-Phenylethyl)azethidinone-2 (101067-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 43 percent / dicyclohexylcarbodiimide / ethyl acetate / 1 h / 0 °C

2: 21 percent / benzene / 120 h / Irradiation

With dicyclohexyl-carbodiimide; In ethyl acetate; benzene;

DOI:10.1016/0040-4020(95)00737-S

upstream raw materials:

succinic acid anhydride

N-(1-phenyl-ethyl)-hydroxylamine

Downstream raw materials:

N-(α-methylbenzyl)tetrahydro-1,2-oxazine-3,6-dione

(+/-)-1-(α-Phenylethyl)azethidinone-2