benzyl 3,5-dimethyl-4-(trifluoroacetyl)pyrrole-2-carboxylate

Base Information

• Chemical Name: benzyl 3,5-dimethyl-4-(trifluoroacetyl)pyrrole-2-carboxylate
• CAS No.: 205492-38-2
• Molecular Formula: C₁₆H₁₄F₃NO₃
• Molecular Weight: 325.287
• Mol file: 205492-38-2.mol

Synonyms:benzyl 3,5-dimethyl-4-(trifluoroacetyl)pyrrole-2-carboxylate

Chemical Property of benzyl 3,5-dimethyl-4-(trifluoroacetyl)pyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of benzyl 3,5-dimethyl-4-(trifluoroacetyl)pyrrole-2-carboxylate

There total 3 articles about benzyl 3,5-dimethyl-4-(trifluoroacetyl)pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzyl 4-(1-hydroxy-2,2,2-trifluoroethyl)-3,5-dimethylpyrrole-2-carboxylate (184775-08-4) → benzyl 3,5-dimethyl-4-(trifluoroacetyl)pyrrole-2-carboxylate (205492-38-2)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 30h;

DOI:10.1016/S0040-4020(01)00780-3

Reference yield: 87.0%

benzyl 3,5-dimethylpyrrole-2-carboxylate (40236-19-9) + trifluoroacetic anhydride (407-25-0) → benzyl 3,5-dimethyl-4-(trifluoroacetyl)pyrrole-2-carboxylate (205492-38-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jo051906w

Reference yield:

benzyl 3,5-dimethylpyrrole-2-carboxylate (40236-19-9) → benzyl 3,5-dimethyl-4-(trifluoroacetyl)pyrrole-2-carboxylate (205492-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / ZnCl₂

2: 98 percent / Dess-Martin reagent / CH₂Cl₂ / 30 h / 20 °C

With Dess-Martin periodane; zinc(II) chloride; In dichloromethane;

DOI:10.1016/S0040-4020(01)00780-3

upstream raw materials:

benzyl 4-(1-hydroxy-2,2,2-trifluoroethyl)-3,5-dimethylpyrrole-2-carboxylate

benzyl 3,5-dimethylpyrrole-2-carboxylate

trifluoroacetic anhydride

Downstream raw materials:

benzyl 3,5-dimethyl-4-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrole-2-carboxylate

benzyl (S)-4-(1-hydroxy-2,2,2-trifluoroethyl)-3,5-dimethylpyrrole-2-carboxylate

benzyl 4-methyl-3-((S)-2,2,2-trifluoro-1-hydroxyethyl)pyrrole-2-carboxylate

benzyl 4-methyl-3-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrole-2-carboxylate