(Z)-2-Formylamino-3-[4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acrylic acid ethyl ester

Base Information

Chemical Name:(Z)-2-Formylamino-3-[4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acrylic acid ethyl ester
CAS No.:98665-04-4
Molecular Formula:C₂₇H₃₀N₂O₇S
Molecular Weight:526.61
Hs Code.:

Synonyms:(Z)-2-Formylamino-3-[4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acrylic acid ethyl ester

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Chemical Property of (Z)-2-Formylamino-3-[4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acrylic acid ethyl ester

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Technology Process of (Z)-2-Formylamino-3-[4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acrylic acid ethyl ester

There total 1 articles about (Z)-2-Formylamino-3-[4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98664-98-3
5-[4-[2-(2-Methyl-[1,3]dioxolan-2-yl)-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-4,5-dihydro-oxazole-4-carboxylic acid ethyl ester

: 98665-05-5
N-{(E)-2-[4-[2-(2-Methyl-[1,3]dioxolan-2-yl)-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-vinyl}-formamide

: 98664-99-4
(E)-2-Formylamino-3-[4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acrylic acid ethyl ester

: 98665-04-4
(Z)-2-Formylamino-3-[4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acrylic acid ethyl ester

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -20 ℃; for 0.5h; Yield given. Yields of byproduct given;

Reference yield:

: 98665-04-4
(Z)-2-Formylamino-3-[4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acrylic acid ethyl ester

: 98664-91-6
C₃₃H₃₄N₂O₆S

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) 50 percent NaH / 1.) DMF, 0 deg C, 20 min, 2.) THF, from -83 deg C to -20 deg C, 30 min

2: 94 percent / acetone, p-Ts-OH / 14 h / Ambient temperature

3: 52 percent / DBU / benzene / 6 h

4: 27 percent / DBU / benzene / 3.5 h

5: 2.) 50 percent NaH / 1.) THF, -80 deg C, 20 min, 2.) DMF, THF, from 0 deg C to RT, 1 h

6: 58 percent / 1 N HCl / dimethylsulfoxide; ethanol; H₂O / 2 h / Heating

7: 77 percent / Et₃N / CH₂Cl₂ / -20 - 20 °C

8: 1.) SiO₂ / 1.) CH₂Cl₂, -82 deg C, 15 min, 2.) CH₂Cl₂, RT, 1.5 h

9: 35 percent / Raney Ni / ethanol / 4 h / Heating

With hydrogenchloride; silica gel; sodium hydride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; acetone; nickel; In ethanol; dichloromethane; water; dimethyl sulfoxide; benzene;

Reference yield:

: 98665-04-4
(Z)-2-Formylamino-3-[4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acrylic acid ethyl ester

: 98664-90-5,98718-38-8,98718-39-9
(6aS,9S,9aR)-7,7-Dimethyl-2-(toluene-4-sulfonyl)-2,6a,7,8,9,9a-hexahydro-6H-isoindolo[4,5,6-cd]indole-9-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) 50 percent NaH / 1.) DMF, 0 deg C, 20 min, 2.) THF, from -83 deg C to -20 deg C, 30 min

2: 94 percent / acetone, p-Ts-OH / 14 h / Ambient temperature

3: 52 percent / DBU / benzene / 6 h

4: 27 percent / DBU / benzene / 3.5 h

5: 2.) 50 percent NaH / 1.) THF, -80 deg C, 20 min, 2.) DMF, THF, from 0 deg C to RT, 1 h

6: 58 percent / 1 N HCl / dimethylsulfoxide; ethanol; H₂O / 2 h / Heating

7: 77 percent / Et₃N / CH₂Cl₂ / -20 - 20 °C

8: 1.) SiO₂ / 1.) CH₂Cl₂, -82 deg C, 15 min, 2.) CH₂Cl₂, RT, 1.5 h

9: 36 percent / Raney Ni / ethanol / 4 h / Heating

With hydrogenchloride; silica gel; sodium hydride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; acetone; nickel; In ethanol; dichloromethane; water; dimethyl sulfoxide; benzene;