7-<3-(methoxyimino)pyrrolidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Base Information

Chemical Name:7-<3-(methoxyimino)pyrrolidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
CAS No.:139524-72-4
Molecular Formula:C₂₀H₁₅F₃N₄O₄
Molecular Weight:432.359
Hs Code.:

Synonyms:7-<3-(methoxyimino)pyrrolidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

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Chemical Property of 7-<3-(methoxyimino)pyrrolidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

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Technology Process of 7-<3-(methoxyimino)pyrrolidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

There total 3 articles about 7-<3-(methoxyimino)pyrrolidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 593-56-6
N-methoxylamine hydrochloride

: 1-(2,4-Difluoro-phenyl)-6-fluoro-4-oxo-7-(3-oxo-pyrrolidin-1-yl)-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid

: 139524-72-4
7-<3-(methoxyimino)pyrrolidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: With sodium hydrogencarbonate; In ethanol; at 45 ℃; for 20h; Yield given;

Reference yield:

: 100491-29-0
ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

: 139524-72-4
7-<3-(methoxyimino)pyrrolidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / Ambient temperature

2: 3 M aq. HCl / 70 °C

3: aq. NaHCO₃ / ethanol / 20 h / 45 °C

With pyridine; hydrogenchloride; sodium hydrogencarbonate; In ethanol;

Reference yield:

: 139524-61-1
1-(2,4-Difluoro-phenyl)-7-(1,4-dioxa-7-aza-spiro[4.4]non-7-yl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester

: 139524-72-4
7-<3-(methoxyimino)pyrrolidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 3 M aq. HCl / 70 °C

2: aq. NaHCO₃ / ethanol / 20 h / 45 °C

With hydrogenchloride; sodium hydrogencarbonate; In ethanol;