5-Bromo-2-chloro(trifluoromethoxy)benzene

Base Information

• Chemical Name: 5-Bromo-2-chloro(trifluoromethoxy)benzene
• CAS No.: 406232-79-9
• Molecular Formula: C₇H₃BrClF₃O
• Molecular Weight: 275.452
• Hs Code.: 2909309090
• Mol file: 406232-79-9.mol

Synonyms:4-Bromo-1-chloro-2-[(trifluoromethyl)oxy]benzene;4-Bromo-1-chloro-2-trifluoromethoxy-benzene;5-Bromo-2-chloro-1-trifluoromethoxybenzene;

Chemical Property of 5-Bromo-2-chloro(trifluoromethoxy)benzene

Chemical Property:

• Vapor Pressure: 0.622mmHg at 25°C
• Refractive Index: 1.494
• Boiling Point: 194.278 °C at 760 mmHg
• Flash Point: 71.297 °C
• PSA: 9.23000
• Density: 1.744 g/cm³
• LogP: 4.00110

Purity/Quality:

98% ^*data from raw suppliers

4-Bromo-1-chloro-2-(trifluoromethoxy)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-2-chloro(trifluoromethoxy)benzene

There total 3 articles about 5-Bromo-2-chloro(trifluoromethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-bromo-2-(trifluoromethoxy)aniline (175278-09-8) → 4-bromo-1-chloro-2-(trifluoromethyloxy)benzene (406232-79-9)

Guidance literature:

4-bromo-2-(trifluoromethoxy)aniline; With hydrogenchloride; sodium nitrite; In water; at 0 - 2 ℃; for 0.25h;

With copper(l) chloride; In water; at 20 ℃; for 0.416667h; Heating / reflux;

Reference yield:

4-bromo-2-(trifluoromethoxy)aniline (175278-09-8) + copper(II) chloride (7447-39-4) → 4-bromo-1-chloro-2-(trifluoromethyloxy)benzene (406232-79-9)

Guidance literature:

With tert.-butylnitrite; In acetonitrile;

Reference yield:

2-trifluoromethoxy aniline (1535-75-7) → 4-bromo-1-chloro-2-(trifluoromethyloxy)benzene (406232-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; N-Bromosuccinimide / 0 - 20 °C

2: isopentyl nitrite; copper dichloride / acetonitrile / 3 h / 70 °C

With N-Bromosuccinimide; acetic acid; copper dichloride; isopentyl nitrite; In acetonitrile;

upstream raw materials:

4-bromo-2-(trifluoromethoxy)aniline

copper(II) chloride

2-trifluoromethoxy aniline

Downstream raw materials:

4-chloro-3-(trifluoromethoxy)phenylboronic acid

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