10.1002/jhet.139
The research explores the synthesis and biological evaluation of fluorinated dibenzofuran derivatives. The study aims to investigate the impact of incorporating fluorine into organic molecules on their pharmacological properties, specifically focusing on their potential antimicrobial, antiviral, and antioxidant activities. Key chemicals used in the research include 4-difluoromethoxy-dibenzofuran-1-carboxaldehyde, various 2-hydroxy acetophenones, copper chloride, and 2-aminothiophenol. The synthesized compounds were subjected to biological screening, which revealed that none of the tested compounds exhibited significant antioxidant, antimicrobial, or antiviral activities. The study concludes that while fluorine incorporation is known to enhance pharmacological properties in many compounds, the specific derivatives synthesized in this study did not demonstrate the expected biological activities. This suggests that further modifications or different synthetic approaches may be necessary to achieve the desired biological effects.