methyl 3-(3-(4-isobutyryl piperazine-1-carbonyl)phenyl)-4-oxo-2-(pyridin-4-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate

Base Information

Chemical Name:methyl 3-(3-(4-isobutyryl piperazine-1-carbonyl)phenyl)-4-oxo-2-(pyridin-4-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate
CAS No.:1207453-57-3
Molecular Formula:C₃₁H₃₂N₄O₅
Molecular Weight:540.619
Hs Code.:

Synonyms:methyl 3-(3-(4-isobutyryl piperazine-1-carbonyl)phenyl)-4-oxo-2-(pyridin-4-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate

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Chemical Property of methyl 3-(3-(4-isobutyryl piperazine-1-carbonyl)phenyl)-4-oxo-2-(pyridin-4-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate

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Technology Process of methyl 3-(3-(4-isobutyryl piperazine-1-carbonyl)phenyl)-4-oxo-2-(pyridin-4-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate

There total 7 articles about methyl 3-(3-(4-isobutyryl piperazine-1-carbonyl)phenyl)-4-oxo-2-(pyridin-4-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1207453-56-2
(E)-4-(pyridin-4-ylmethyleneamino)isobenzofuran-1(3H)-one

: 1207453-12-0
3-(4-isobutyrylpiperazine-1-carbonyl)benzaldehyde

: 124-41-4
sodium methylate

: 1207453-57-3
methyl 3-(3-(4-isobutyryl piperazine-1-carbonyl)phenyl)-4-oxo-2-(pyridin-4-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate

Guidance literature:: In methanol; Ethyl propionate; at 0 - 25 ℃;

Reference yield: 26.0%

: 1207453-56-2
(E)-4-(pyridin-4-ylmethyleneamino)isobenzofuran-1(3H)-one

: 1207453-12-0
3-(4-isobutyrylpiperazine-1-carbonyl)benzaldehyde

: 124-41-4
sodium methylate

: 105-37-3,20741-13-3
Ethyl propionate

: 1207453-57-3
methyl 3-(3-(4-isobutyryl piperazine-1-carbonyl)phenyl)-4-oxo-2-(pyridin-4-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate

Guidance literature:: In methanol; at 0 - 25 ℃; for 18h;

Reference yield:

: 641-70-3
3-nitrophthalic acid anhydride

: 1207453-57-3
methyl 3-(3-(4-isobutyryl piperazine-1-carbonyl)phenyl)-4-oxo-2-(pyridin-4-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 °C

1.2: pH 1

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

3.1: sodium sulfate / ethanol / 144 h / 20 °C / Reflux

4.1: methanol / 18 h / 0 - 25 °C

With sodium tetrahydroborate; hydrogen; sodium sulfate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; ethyl acetate;