6-methoxy-8-(4-methoxyphenyl)-2-phenethyl-1,2,3,4-tetrahydroisoquinolin-7-ol

Base Information

Chemical Name:6-methoxy-8-(4-methoxyphenyl)-2-phenethyl-1,2,3,4-tetrahydroisoquinolin-7-ol
CAS No.:1426260-33-4
Molecular Formula:C₂₅H₂₇NO₃
Molecular Weight:389.494
Hs Code.:

Synonyms:6-methoxy-8-(4-methoxyphenyl)-2-phenethyl-1,2,3,4-tetrahydroisoquinolin-7-ol

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Chemical Property of 6-methoxy-8-(4-methoxyphenyl)-2-phenethyl-1,2,3,4-tetrahydroisoquinolin-7-ol

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Technology Process of 6-methoxy-8-(4-methoxyphenyl)-2-phenethyl-1,2,3,4-tetrahydroisoquinolin-7-ol

There total 4 articles about 6-methoxy-8-(4-methoxyphenyl)-2-phenethyl-1,2,3,4-tetrahydroisoquinolin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1426260-31-2
8-bromo-6-methoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinolin-7-ol

: 5720-07-0
4-methoxyphenylboronic acid

: 1426260-33-4
6-methoxy-8-(4-methoxyphenyl)-2-phenethyl-1,2,3,4-tetrahydroisoquinolin-7-ol

Guidance literature:: With palladium diacetate; sodium carbonate; triphenylphosphine; In water; isopropyl alcohol; at 140 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 103-63-9
1-phenyl-2-bromoethane

: 1426260-33-4
6-methoxy-8-(4-methoxyphenyl)-2-phenethyl-1,2,3,4-tetrahydroisoquinolin-7-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropyl alcohol / 15 h / Reflux

1.2: 0.17 h / Inert atmosphere

2.1: lead(IV) tetraacetate; acetic acid / 20 °C

2.2: 20 °C

3.1: triphenylphosphine; sodium carbonate; palladium diacetate / isopropyl alcohol; water / 0.17 h / 140 °C / Microwave irradiation

With lead(IV) tetraacetate; palladium diacetate; sodium carbonate; acetic acid; triphenylphosphine; In water; isopropyl alcohol; 3.1: |Suzuki Coupling;

Reference yield:

: 4602-73-7
3,4-dihydro-7-hydroxy-6-methoxy-isoquinoline

: 1426260-33-4
6-methoxy-8-(4-methoxyphenyl)-2-phenethyl-1,2,3,4-tetrahydroisoquinolin-7-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropyl alcohol / 15 h / Reflux

1.2: 0.17 h / Inert atmosphere

2.1: lead(IV) tetraacetate; acetic acid / 20 °C

2.2: 20 °C

3.1: triphenylphosphine; sodium carbonate; palladium diacetate / isopropyl alcohol; water / 0.17 h / 140 °C / Microwave irradiation

With lead(IV) tetraacetate; palladium diacetate; sodium carbonate; acetic acid; triphenylphosphine; In water; isopropyl alcohol; 3.1: |Suzuki Coupling;