5-(3-(2,4-difluorophenyl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-ol

Base Information

Chemical Name:5-(3-(2,4-difluorophenyl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-ol
CAS No.:1401345-33-2
Molecular Formula:C₁₆H₉F₂N₃OS
Molecular Weight:329.33
Hs Code.:

Synonyms:5-(3-(2,4-difluorophenyl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-ol

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Chemical Property of 5-(3-(2,4-difluorophenyl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-ol

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Technology Process of 5-(3-(2,4-difluorophenyl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-ol

There total 5 articles about 5-(3-(2,4-difluorophenyl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.28%

: 1401349-00-5
2-(3-(2,4-difluorophenyl)-1-tosyl-1H-indol-5-yl)-5-(methylsulfonyl)-1,3,4-thiadiazole

: 1401345-33-2
5-(3-(2,4-difluorophenyl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-ol

Guidance literature:: 2-(3-(2,4-difluorophenyl)-1-tosyl-1H-indol-5-yl)-5-(methylsulfonyl)-1,3,4-thiadiazole; With sodium hydroxide; In 1,4-dioxane; at 100 - 120 ℃; for 0.333333h; Microwave irradiation;

With trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1401348-60-4
2-(1H-indol-5-yl)-5-(methylthio)-1,3,4-thiadiazole

: 1401345-33-2
5-(3-(2,4-difluorophenyl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 2 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 8 h / 20 °C

3: sodium tungstate; dihydrogen peroxide / water; acetic acid / 72 h / 20 °C

4: potassium phosphate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / isopropyl alcohol; water / 2 h / 80 °C

5: sodium hydroxide / 1,4-dioxane / 0.33 h / 100 - 120 °C / Microwave irradiation

With sodium tungstate; potassium phosphate; dihydrogen peroxide; iodine; sodium hydride; potassium hydroxide; sodium hydroxide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

Reference yield:

: 1401348-61-5
2-(3-iodo-1H-indol-5-yl)-5-(methylthio)-1,3,4-thiadiazole

: 1401345-33-2
5-(3-(2,4-difluorophenyl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 8 h / 20 °C

2: sodium tungstate; dihydrogen peroxide / water; acetic acid / 72 h / 20 °C

3: potassium phosphate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / isopropyl alcohol; water / 2 h / 80 °C

4: sodium hydroxide / 1,4-dioxane / 0.33 h / 100 - 120 °C / Microwave irradiation

With sodium tungstate; potassium phosphate; dihydrogen peroxide; sodium hydride; sodium hydroxide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;