2-(3-iodo-1-tosyl-1H-indol-5-yl)-5-(methylsulfonyl)-1,3,4-thiadiazole

Base Information

Chemical Name:2-(3-iodo-1-tosyl-1H-indol-5-yl)-5-(methylsulfonyl)-1,3,4-thiadiazole
CAS No.:1401348-66-0
Molecular Formula:C₁₈H₁₄IN₃O₄S₃
Molecular Weight:559.429
Hs Code.:

Synonyms:2-(3-iodo-1-tosyl-1H-indol-5-yl)-5-(methylsulfonyl)-1,3,4-thiadiazole

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Chemical Property of 2-(3-iodo-1-tosyl-1H-indol-5-yl)-5-(methylsulfonyl)-1,3,4-thiadiazole

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Technology Process of 2-(3-iodo-1-tosyl-1H-indol-5-yl)-5-(methylsulfonyl)-1,3,4-thiadiazole

There total 7 articles about 2-(3-iodo-1-tosyl-1H-indol-5-yl)-5-(methylsulfonyl)-1,3,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401348-65-9
2-(3-iodo-1-tosyl-1H-indol-5-yl)-5-(methylthio)-1,3,4-thiadiazole

: 1401350-38-6
2-(3-iodo-1-tosyl-1H-indol-5-yl)-5-(methylsulfinyl)-1,3,4-thiadiazole

: 1401348-66-0
2-(3-iodo-1-tosyl-1H-indol-5-yl)-5-(methylsulfonyl)-1,3,4-thiadiazole

Guidance literature:: With sodium tungstate; dihydrogen peroxide; In water; acetic acid; at 20 ℃; for 72h;

Reference yield:

: 1401348-61-5
2-(3-iodo-1H-indol-5-yl)-5-(methylthio)-1,3,4-thiadiazole

: 1401348-66-0
2-(3-iodo-1-tosyl-1H-indol-5-yl)-5-(methylsulfonyl)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide

2: dihydrogen peroxide; sodium tungstate / acetic acid

With sodium tungstate; dihydrogen peroxide; sodium hydride; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.12.091

Reference yield:

: 269410-24-4
5-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole

: 1401348-66-0
2-(3-iodo-1-tosyl-1H-indol-5-yl)-5-(methylsulfonyl)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane

2: iodine; potassium hydroxide

3: sodium hydride / N,N-dimethyl-formamide

4: dihydrogen peroxide; sodium tungstate / acetic acid

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium tungstate; dihydrogen peroxide; iodine; sodium hydride; potassium carbonate; potassium hydroxide; In 1,4-dioxane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.12.091