(S)-5-broMo-3-((1-Methylpyrrolidin-2-yl)Methyl)-1H-indole

Base Information

Chemical Name:(S)-5-broMo-3-((1-Methylpyrrolidin-2-yl)Methyl)-1H-indole
CAS No.:208464-41-9
Molecular Formula:C₁₄H₁₇BrN₂
Molecular Weight:293.206
Hs Code.:
Mol file:208464-41-9.mol

Synonyms:1H-Indole, 5-bromo-3-[[(2S)-1-methyl-2-pyrrolidinyl]methyl]-;

Suppliers and Price of (S)-5-broMo-3-((1-Methylpyrrolidin-2-yl)Methyl)-1H-indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Bromo-3-[[(2S)-1-methyl-2-pyrrolidinyl]methyl]-1H-indole
2.5mg
$ 205.00

Chemenu
(S)-5-bromo-3-((1-methylpyrrolidin-2-yl)methyl)-1H-indole 95%+
1g
$ 970.00

Chemenu
(S)-5-bromo-3-((1-methylpyrrolidin-2-yl)methyl)-1H-indole 95%+
250mg
$ 307.00

Chemenu
(S)-5-bromo-3-((1-methylpyrrolidin-2-yl)methyl)-1H-indole 95%+
100mg
$ 268.00

Total 6 raw suppliers

Chemical Property of (S)-5-broMo-3-((1-Methylpyrrolidin-2-yl)Methyl)-1H-indole

Chemical Property:

PSA：19.03000
LogP:3.50500
Solubility.:DCM, Methanol

Purity/Quality:

≥95% ^*data from raw suppliers

5-Bromo-3-[[(2S)-1-methyl-2-pyrrolidinyl]methyl]-1H-indole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 5-Bromo-3-[[(2S)-1-methyl-2-pyrrolidinyl]methyl]-1H-indole is an intermediate in the synthesis of ent-Eletriptan (E505005), an enantiomeric impurity of the serotonin 5-HTIB/ID receptor agonist Eletriptan (E505000).

Technology Process of (S)-5-broMo-3-((1-Methylpyrrolidin-2-yl)Methyl)-1H-indole

There total 11 articles about (S)-5-broMo-3-((1-Methylpyrrolidin-2-yl)Methyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

: 1196663-29-2
5-bromo-3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-1H-indole ethanedioate

: 143322-57-0,208464-41-9,312949-16-9
(R)-5-bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole

Guidance literature:: With sodium carbonate; In water; toluene; at 30 - 35 ℃; for 0.5h; pH=7.8;

Reference yield: 77.0%

: 143322-56-9,331842-86-5
(R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-bromo-1H-indole

: 143322-55-8
(R)-3-(1-methyl-2-pyrrolidinylmethyl)-1H-indole

: C₁₄H₁₇BrN₂O

: 180637-93-8
C₁₄H₁₅BrN₂O

: 143322-57-0,208464-41-9,312949-16-9
(R)-5-bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole

Guidance literature:: (R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-bromo-1H-indole; With sodium bis(2-methoxyethoxy)aluminium dihydride; In tert-butyl methyl ether; toluene; at 30 - 48 ℃; for 3.16667h;

With sodium hydroxide; water; In tert-butyl methyl ether; toluene; at 15 - 20 ℃; for 0.5h; Product distribution / selectivity;

Reference yield: 73.0%

: 143322-56-9,331842-86-5
(R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-bromo-1H-indole

: 143322-57-0,208464-41-9,312949-16-9
(R)-5-bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole

Guidance literature:: (R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-bromo-1H-indole; With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; at 30 - 50 ℃; for 1.66667 - 2h;

With sodium hydroxide; water; In tetrahydrofuran; toluene; at 5 - 25 ℃; Product distribution / selectivity;