2-({2-[4-(4-fluorophenylamino)-6-(2-hydroxyethyl)pyrimidin-2-yl]hydrazono}methyl)phenol

Base Information

Chemical Name:2-({2-[4-(4-fluorophenylamino)-6-(2-hydroxyethyl)pyrimidin-2-yl]hydrazono}methyl)phenol
CAS No.:1279692-20-4
Molecular Formula:C₁₉H₁₈FN₅O₂
Molecular Weight:367.383
Hs Code.:

Synonyms:2-({2-[4-(4-fluorophenylamino)-6-(2-hydroxyethyl)pyrimidin-2-yl]hydrazono}methyl)phenol

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Chemical Property of 2-({2-[4-(4-fluorophenylamino)-6-(2-hydroxyethyl)pyrimidin-2-yl]hydrazono}methyl)phenol

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Technology Process of 2-({2-[4-(4-fluorophenylamino)-6-(2-hydroxyethyl)pyrimidin-2-yl]hydrazono}methyl)phenol

There total 7 articles about 2-({2-[4-(4-fluorophenylamino)-6-(2-hydroxyethyl)pyrimidin-2-yl]hydrazono}methyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1279692-49-7
2-[(2-{4-[2-(tert-butyldiphenylsilyloxy)ethyl]-6-(4-fluorophenylamino)pyrimidin-2-yl}hydrazono)methyl]phenol

: 1279692-20-4
2-({2-[4-(4-fluorophenylamino)-6-(2-hydroxyethyl)pyrimidin-2-yl]hydrazono}methyl)phenol

Guidance literature:: 2-[(2-{4-[2-(tert-butyldiphenylsilyloxy)ethyl]-6-(4-fluorophenylamino)pyrimidin-2-yl}hydrazono)methyl]phenol; With triethylamine tris(hydrogen fluoride); In tetrahydrofuran; at 20 ℃;

With sodium hydrogencarbonate; In tetrahydrofuran;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1279692-20-4
2-({2-[4-(4-fluorophenylamino)-6-(2-hydroxyethyl)pyrimidin-2-yl]hydrazono}methyl)phenol

Guidance literature:: Multi-step reaction with 6 steps

1: 1,2-dimethoxyethane / 0.08 h / 150 °C / Microwave irradiation

2: Oxone / water; tetrahydrofuran; methanol / 20 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 0.08 h / 100 °C / Microwave irradiation

4: hydrazine hydrate / 1,2-dimethoxyethane / 0.08 h / 120 °C / Microwave irradiation

5: toluene / 2 h / Molecular sieve; Reflux

6: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 20 °C

With 1H-imidazole; Oxone; hydrazine hydrate; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1279692-43-1
2-[6-(4-fluorophenylamino)-2-(methylthio)pyrimidin-4-yl]ethanol

: 1279692-20-4
2-({2-[4-(4-fluorophenylamino)-6-(2-hydroxyethyl)pyrimidin-2-yl]hydrazono}methyl)phenol

Guidance literature:: Multi-step reaction with 5 steps

1: Oxone / water; tetrahydrofuran; methanol / 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 0.08 h / 100 °C / Microwave irradiation

3: hydrazine hydrate / 1,2-dimethoxyethane / 0.08 h / 120 °C / Microwave irradiation

4: toluene / 2 h / Molecular sieve; Reflux

5: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 20 °C

With 1H-imidazole; Oxone; hydrazine hydrate; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene;