tert-butyl 4-{2-(2,4-dimethoxybenzyl)-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-{2-(2,4-dimethoxybenzyl)-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}piperidine-1-carboxylate
CAS No.:1429501-76-7
Molecular Formula:C₃₃H₃₈F₃N₃O₆
Molecular Weight:629.676
Hs Code.:

Synonyms:tert-butyl 4-{2-(2,4-dimethoxybenzyl)-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-{2-(2,4-dimethoxybenzyl)-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}piperidine-1-carboxylate

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Technology Process of tert-butyl 4-{2-(2,4-dimethoxybenzyl)-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-{2-(2,4-dimethoxybenzyl)-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1429500-85-5
tert-butyl 4-[2-(2,4-dimethoxybenzyl)-7-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]piperidine-1 carboxylate

: 179113-90-7
(3-(trifluoromethoxy)phenyl)boronic acid

: 1429501-76-7
tert-butyl 4-{2-(2,4-dimethoxybenzyl)-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}piperidine-1-carboxylate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; water; at 90 ℃; for 4h; Inert atmosphere; Sealed tube;

Reference yield:

: 137076-22-3
tert butyl 4-formylpiperidine-1-carboxylate

: 1429501-76-7
tert-butyl 4-{2-(2,4-dimethoxybenzyl)-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran; nitromethane; tert-butyl alcohol

3: acetic acid; sodium cyanoborohydride / tetrahydrofuran

4: N-ethyl-N,N-diisopropylamine / 1,4-dioxane

5: triethanolamine / water; ethyl acetate

6: caesium carbonate / water; 1,4-dioxane

With triethanolamine; sodium cyanoborohydride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; nitromethane; water; ethyl acetate; tert-butyl alcohol;

Reference yield:

: 1429500-83-3
tert-butyl 4-(2-{(2,4-dimethoxybenzyl)[(4-iodo-1H-pyrrol-2-yl)carbonyl]amino}-1-hydroxyethyl)piperidine-1-carboxylate

: 1429501-76-7
tert-butyl 4-{2-(2,4-dimethoxybenzyl)-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethanolamine / water; ethyl acetate

2: caesium carbonate / water; 1,4-dioxane

With triethanolamine; caesium carbonate; In 1,4-dioxane; water; ethyl acetate;