N-(3-(2-(3-fluoro-4-(4-methylpiperazin-1-yl)phenylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide

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Chemical Name:N-(3-(2-(3-fluoro-4-(4-methylpiperazin-1-yl)phenylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide
CAS No.:1557268-64-0
Molecular Formula:C₃₂H₄₀FN₇O₃Si
Molecular Weight:617.799
Hs Code.:

Synonyms:N-(3-(2-(3-fluoro-4-(4-methylpiperazin-1-yl)phenylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide

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Chemical Property of N-(3-(2-(3-fluoro-4-(4-methylpiperazin-1-yl)phenylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide

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Technology Process of N-(3-(2-(3-fluoro-4-(4-methylpiperazin-1-yl)phenylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide

There total 7 articles about N-(3-(2-(3-fluoro-4-(4-methylpiperazin-1-yl)phenylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1557268-61-7
4-(3-aminophenoxy)-N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-7-((2-(trimethylsilyl)ethyloxy)methyl)-7H-pyrrolo[2,3-D]pyrimidin-2-amine

: 814-68-6,25189-84-8
acryloyl chloride

: 1557268-64-0
N-(3-(2-(3-fluoro-4-(4-methylpiperazin-1-yl)phenylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1.16667h;

Reference yield: 75.0%

: 1557268-64-0
N-(3-(2-(3-fluoro-4-(4-methylpiperazin-1-yl)phenylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1557268-64-0
N-(3-(2-(3-fluoro-4-(4-methylpiperazin-1-yl)phenylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3: potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 80 °C / Inert atmosphere

4: iron; ammonium chloride / ethanol; water / 2 h / Reflux; Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.17 h / 0 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; sodium hydride; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; XPhos; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;