4-(3-aminophenoxy)-N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-7-((2-(trimethylsilyl)ethyloxy)methyl)-7H-pyrrolo[2,3-D]pyrimidin-2-amine

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Chemical Name:4-(3-aminophenoxy)-N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-7-((2-(trimethylsilyl)ethyloxy)methyl)-7H-pyrrolo[2,3-D]pyrimidin-2-amine
CAS No.:1557268-61-7
Molecular Formula:C₂₉H₃₈FN₇O₂Si
Molecular Weight:563.75
Hs Code.:

Synonyms:4-(3-aminophenoxy)-N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-7-((2-(trimethylsilyl)ethyloxy)methyl)-7H-pyrrolo[2,3-D]pyrimidin-2-amine

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Chemical Property of 4-(3-aminophenoxy)-N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-7-((2-(trimethylsilyl)ethyloxy)methyl)-7H-pyrrolo[2,3-D]pyrimidin-2-amine

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Technology Process of 4-(3-aminophenoxy)-N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-7-((2-(trimethylsilyl)ethyloxy)methyl)-7H-pyrrolo[2,3-D]pyrimidin-2-amine

There total 6 articles about 4-(3-aminophenoxy)-N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-7-((2-(trimethylsilyl)ethyloxy)methyl)-7H-pyrrolo[2,3-D]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

: 1557268-58-2
N-(3-fluoro-4- (4-methylpiperazin-1-yl)phenyl)-4-(3-nitrophenoxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-D]pyrimidin-2-amine

: 1557268-61-7
4-(3-aminophenoxy)-N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-7-((2-(trimethylsilyl)ethyloxy)methyl)-7H-pyrrolo[2,3-D]pyrimidin-2-amine

Guidance literature:: With iron; ammonium chloride; In ethanol; water; for 2h; Reflux; Inert atmosphere;

Reference yield: 85.0%

: 1557268-61-7
4-(3-aminophenoxy)-N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-7-((2-(trimethylsilyl)ethyloxy)methyl)-7H-pyrrolo[2,3-D]pyrimidin-2-amine

Guidance literature:: With iron; ammonium chloride; In ethanol; water; for 3h; Reflux;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1557268-61-7
4-(3-aminophenoxy)-N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-7-((2-(trimethylsilyl)ethyloxy)methyl)-7H-pyrrolo[2,3-D]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3: potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 80 °C / Inert atmosphere

4: iron; ammonium chloride / ethanol; water / 2 h / Reflux; Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; sodium hydride; potassium carbonate; ammonium chloride; XPhos; In ethanol; water; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;