N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

Base Information

Chemical Name:N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide
CAS No.:1443276-53-6
Molecular Formula:C₂₇H₃₇N₇O
Molecular Weight:475.637
Hs Code.:

Synonyms:N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

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Chemical Property of N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

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Technology Process of N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

There total 9 articles about N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 109-01-3
1-methyl-piperazine

: 1443276-45-6
3-chloro-N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)propanamide

: 1443276-53-6
N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

Guidance literature:: In methanol; ethanol; for 6h; Reflux;
DOI:10.1016/j.ejmech.2013.01.051

Reference yield:

: 610-14-0
2-nitrobenzyl chloride

: 1443276-53-6
N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / chloroform / 5 h / 20 °C

2: potassium hydroxide / ethanol / 2 h / Reflux

3: N,N-diethylaniline; trichlorophosphate / toluene / 6 h / 80 °C

4: tetrahydrofuran / 5 h / Reflux

5: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 5 h / Reflux

6: dichloromethane / 0 - 20 °C

7: ethanol; methanol / 6 h / Reflux

With hydrogenchloride; tin(II) chloride dihdyrate; triethylamine; N,N-diethylaniline; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; toluene;
DOI:10.1016/j.ejmech.2013.01.051

Reference yield:

: 36567-87-0
2-(2'-nitrophenyl)-4(3H)-quinazolinone

: 1443276-53-6
N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-diethylaniline; trichlorophosphate / toluene / 6 h / 80 °C

2: tetrahydrofuran / 5 h / Reflux

3: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 5 h / Reflux

4: dichloromethane / 0 - 20 °C

5: ethanol; methanol / 6 h / Reflux

With hydrogenchloride; tin(II) chloride dihdyrate; N,N-diethylaniline; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;
DOI:10.1016/j.ejmech.2013.01.051