Ethyl 6-(benzyloxy)-1H-indazole-3-carboxylate

Base Information

Chemical Name:Ethyl 6-(benzyloxy)-1H-indazole-3-carboxylate
CAS No.:865887-12-3
Molecular Formula:C17H16 N2 O3
Molecular Weight:296.326
Hs Code.:
DSSTox Substance ID:DTXSID00699958
Wikidata:Q82631082
Mol file:865887-12-3.mol

Synonyms:ETHYL 6-(BENZYLOXY)-1H-INDAZOLE-3-CARBOXYLATE;6-Benzyloxy-1H-indazole-3-carboxylic acid ethyl ester;SCHEMBL492250;DTXSID00699958;DQFLWHXQVSWZPA-UHFFFAOYSA-N;6-(Phenylmethoxy)-1H-indazole-3-carboxylic acid ethyl ester;SB39163;CS-0456531;FT-0739943

Suppliers and Price of Ethyl 6-(benzyloxy)-1H-indazole-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
6-Benzyloxy-1H-indazole-3-carboxylicacidethylester 97%
5g
$ 3998.00

J&W Pharmlab
6-Benzyloxy-1H-indazole-3-carboxylicacidethylester 97%
1g
$ 998.00

J&W Pharmlab
6-Benzyloxy-1H-indazole-3-carboxylicacidethylester 97%
500mg
$ 299.00

Total 5 raw suppliers

Chemical Property of Ethyl 6-(benzyloxy)-1H-indazole-3-carboxylate

Chemical Property:

PSA：64.21000
LogP:3.31860
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:296.11609238
Heavy Atom Count:22
Complexity:371

Purity/Quality:

97% ^*data from raw suppliers

6-Benzyloxy-1H-indazole-3-carboxylicacidethylester 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=NNC2=C1C=CC(=C2)OCC3=CC=CC=C3

Technology Process of Ethyl 6-(benzyloxy)-1H-indazole-3-carboxylate

There total 3 articles about Ethyl 6-(benzyloxy)-1H-indazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.4%

: 865887-11-2
6-benzyloxy-1H-indazole-3-carboxylic acid

: 64-17-5
ethanol

: 865887-12-3
6-(benzyloxy)-1H-indazole-3-carboxylic acid ethyl ester

Guidance literature:: With hydrogenchloride; for 25h; Product distribution / selectivity; Heating / reflux;

Reference yield:

: 64-17-5
ethanol

: 6-(benzyloxy)-2-{[2-(trimethylsilyl)ethoxy]methyl}-2H-indazole-3-carboxylic acid

: 865887-12-3
6-(benzyloxy)-1H-indazole-3-carboxylic acid ethyl ester

Guidance literature:: With sulfuric acid; In ethanol; Reflux;

Reference yield:

: 6-(benzyloxy)-3-iodo-2-{[2-(trimethylsilyl)ethoxy]methyl}-2H-indazole

: 865887-12-3
6-(benzyloxy)-1H-indazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - 20 °C

1.2: 20 °C

2.1: sulfuric acid / ethanol / Reflux

With n-butyllithium; sulfuric acid; In tetrahydrofuran; ethanol;