N-(3-{[5-cyano-2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-ylamino]methyl}pyridin-2-yl)-N-methylmethanesulfonamide

Base Information

Chemical Name:N-(3-{[5-cyano-2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-ylamino]methyl}pyridin-2-yl)-N-methylmethanesulfonamide
CAS No.:1420885-74-0
Molecular Formula:C₂₂H₁₉FN₆O₂S
Molecular Weight:450.496
Hs Code.:

Synonyms:N-(3-{[5-cyano-2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-ylamino]methyl}pyridin-2-yl)-N-methylmethanesulfonamide

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Chemical Property of N-(3-{[5-cyano-2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-ylamino]methyl}pyridin-2-yl)-N-methylmethanesulfonamide

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Technology Process of N-(3-{[5-cyano-2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-ylamino]methyl}pyridin-2-yl)-N-methylmethanesulfonamide

There total 8 articles about N-(3-{[5-cyano-2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-ylamino]methyl}pyridin-2-yl)-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 939791-42-1
N-(3-(aminomethyl)pyridine-2-yl)-N-methylmethanesulfonamide

: 1420886-05-0
4-chloro-2-(4-fluoro-phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

: 1420885-74-0
N-(3-{[5-cyano-2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-ylamino]methyl}pyridin-2-yl)-N-methylmethanesulfonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 170 ℃; for 2.33333h; Microwave irradiation;

Reference yield: 34.0%

: 1420886-05-0
4-chloro-2-(4-fluoro-phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

: N-(3-aminomethyl-pyridin-2-yl)-N-methyl-methanesulfonamide dihydrochloride

: 1420885-74-0
N-(3-{[5-cyano-2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-ylamino]methyl}pyridin-2-yl)-N-methylmethanesulfonamide

Guidance literature:: With 1-methyl-pyrrolidin-2-one; N-ethyl-N,N-diisopropylamine; at 170 ℃; for 3.33333h; Microwave irradiation;
DOI:10.1021/jm3016014

Reference yield:

: 1420886-04-9
2-(4-fluoro-phenyl)-7-oxy-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

: 1420885-74-0
N-(3-{[5-cyano-2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-ylamino]methyl}pyridin-2-yl)-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 3 h / 85 °C

2: 1-methyl-pyrrolidin-2-one; N-ethyl-N,N-diisopropylamine / 3.33 h / 170 °C / Microwave irradiation

With 1-methyl-pyrrolidin-2-one; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
DOI:10.1021/jm3016014