N-(3-(aminomethyl)pyridin-2-yl)-N-methylmethanesulfonamide

Base Information

• Chemical Name: N-(3-(aminomethyl)pyridin-2-yl)-N-methylmethanesulfonamide
• CAS No.: 939791-42-1
• Molecular Formula: C8H13N3O2S
• Molecular Weight: 215.276
• Hs Code.: 2935009090
• Mol file: 939791-42-1.mol

Synonyms:LogP

Chemical Property of N-(3-(aminomethyl)pyridin-2-yl)-N-methylmethanesulfonamide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 386.047°C at 760 mmHg
• Flash Point: 187.275°C
• PSA: 84.67000
• Density: 1.332g/cm³
• LogP: 1.71720
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

N-(3-(aminomethyl)pyridin-2-yl)-N-methylmethanesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3-(aminomethyl)pyridin-2-yl)-N-methylmethanesulfonamide

There total 4 articles about N-(3-(aminomethyl)pyridin-2-yl)-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-(3-cyanopyridin-2-yl)-N-methylmethanesulfonamide (73161-37-2) → N-(3-(aminomethyl)pyridine-2-yl)-N-methylmethanesulfonamide (939791-42-1)

Guidance literature:

With ammonia; hydrogen; palladium 10% on activated carbon; In methanol; water; under 2585.81 Torr;

Reference yield: 88.0%

tert-butyl (2-(N-methylmethylsulfonamido)pyridin-3-yl)methylcarbamate (1061357-93-4) → N-(3-(aminomethyl)pyridine-2-yl)-N-methylmethanesulfonamide (939791-42-1)

Guidance literature:

tert-butyl (2-(N-methylmethylsulfonamido)pyridin-3-yl)methylcarbamate; With trifluoroacetic acid; In dichloromethane; for 0.333333h;

With Amberlyst A-21; In dichloromethane; for 0.5h;

Reference yield:

3-cyano-2-fluoropyridine (3939-13-7) → N-(3-(aminomethyl)pyridine-2-yl)-N-methylmethanesulfonamide (939791-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / Reflux

2: hydrogen; ammonia / Ra-Ni / water; methanol / 1.25 h / 20 °C / 1551.49 Torr

With potassium tert-butylate; ammonia; hydrogen; Ra-Ni; In methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl (2-(N-methylmethylsulfonamido)pyridin-3-yl)methylcarbamate

N-(3-cyanopyridin-2-yl)-N-methylmethanesulfonamide

3-cyano-2-fluoropyridine

2-chloro-3-pyridinecarbonitrile