3-(Piperazin-1-YL)-1H-indazole

Base Information

• Chemical Name: 3-(Piperazin-1-YL)-1H-indazole
• CAS No.: 131633-88-0
• Molecular Formula: C11H14 N4
• Molecular Weight: 202.259
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID80564433
• Wikidata: Q82449122
• Mol file: 131633-88-0.mol

Synonyms:3-(PIPERAZIN-1-YL)-1H-INDAZOLE;131633-88-0;3-piperazin-1-yl-1H-indazole;1H-Indazole, 3-(1-piperazinyl)-;3-(1-Piperazinyl]-1H-indazole;3-(1-PIPERAZINYL)-1H-INDAZOLE;1H-Indazole,3-(1-piperazinyl)-;3piperazin- 1-yl-1H-indazole;4(1H-indazol-3-yl)piperazine;SCHEMBL1132419;3-piperazin-1-yl-l H-indazole;3-piperazine-1-yl-1H-indazole;3-piperazin-1-yl-1 H-indazole;4-(1H-indazol-3-yl)piperazine;DTXSID80564433;3-(1-piperazinyl)-l H-indazole;HCNSJWYUKDBQNO-UHFFFAOYSA-N;4-(1 H-indazol-3-yl)piperazine;3 -(1-Piperazinyl)-1H-indazole;3-(1 -Piperazinyl)-1H-indazole;3-(1-Piperazinyl)-1 H-Indazole;AKOS015912259;AB07666;BS-15182;CS-0186719;D82595;J-510931

Chemical Property of 3-(Piperazin-1-YL)-1H-indazole

Chemical Property:

• PSA: 43.95000
• LogP: 1.36630
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 202.121846464
• Heavy Atom Count: 15
• Complexity: 215

Purity/Quality:

97% ^*data from raw suppliers

3-(Piperazin-1-yl)-1H-indazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1)C2=NNC3=CC=CC=C32

Technology Process of 3-(Piperazin-1-YL)-1H-indazole

There total 6 articles about 3-(Piperazin-1-YL)-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

piperazine (110-85-0) + 3-chloroindazole (29110-74-5) → 1-(1H-indazol-3-yl)piperazine (131633-88-0)

Guidance literature:

at 250 ℃; for 14h; Heating / reflux;

Reference yield:

4-(1H-indazol-3-yl)-1-piperazinecarbonitrile (131634-55-4) + sulfuric acid (7664-93-9) → 1-(1H-indazol-3-yl)piperazine (131633-88-0) + benzimidazole (271-44-3)

Guidance literature:

In sodium hydroxide; ethyl acetate;

Reference yield:

4-(1H-indazol-3-yl)-1-piperazinecarbonitrile (131634-55-4) → 1-(1H-indazol-3-yl)piperazine (131633-88-0)

Guidance literature:

With H₂SO₄; In sodium hydroxide; ethyl acetate;

upstream raw materials:

piperazine

3-chloroindazole

4-(1H-indazol-3-yl)-1-piperazinecarbonitrile

sulfuric acid