1H-Pyrrolo[2,3-d]pyrimidin-2-amine (9CI)

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-d]pyrimidin-2-amine (9CI)
• CAS No.: 93366-88-2
• Molecular Formula: C6H6N4
• Molecular Weight: 134.14
• Hs Code.: 2933990090
• Mol file: 93366-88-2.mol

Synonyms:1H-Pyrrolo[2,3-d]pyrimidin-2-amine(9CI);2-Amino-7H-pyrrolo[2,3-d]pyrimidine;

Chemical Property of 1H-Pyrrolo[2,3-d]pyrimidin-2-amine (9CI)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.824
• Boiling Point: 359.786 °C at 760 mmHg
• PKA: 12.05±0.20(Predicted)
• Flash Point: 171.393 °C
• PSA: 68.32000
• Density: 1.619 g/cm³
• LogP: 0.47020
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

7H-Pyrrolo[2,3-d]pyrimidin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-d]pyrimidin-2-amine (9CI)

There total 3 articles about 1H-Pyrrolo[2,3-d]pyrimidin-2-amine (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine (84955-31-7) → 2-Amino-7H-pyrrolo<2,3-d>pyrimidin (93366-88-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/j.bmcl.2007.03.091

Reference yield:

2-chloro-7H-pyrrolo[2,3-d]pyrimidine (335654-06-3) → 2-Amino-7H-pyrrolo<2,3-d>pyrimidin (93366-88-2)

Guidance literature:

With ammonia; In methanol; at 130 ℃; Sealed tube;

Reference yield:

4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine (84955-31-7) → 2-Amino-7H-pyrrolo<2,3-d>pyrimidin (93366-88-2) + 6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-amine (97482-19-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; ammonium formate; In isopropyl alcohol; Reflux;

upstream raw materials:

4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine

2-chloro-7H-pyrrolo[2,3-d]pyrimidine

Downstream raw materials:

2-Amino-7-<2-desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidin

2-Amino-7-<2-desoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidin

2-Amino-7-(2-desoxy-α-D-erythro-pentofuranosyl)-7H-pyrrolo<2,3-d>pyrimidin

C₁₉H₂₄N₆OSi

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