335654-06-3

Basic information

• Product Name: 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE
• Synonyms: 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE;2-Chloro-1H-pyrrolo[2,3-d]pyrimidine;2-Chloro-7H-pyrrolo[2,3-d...;2-Chloro-7-deazapurine;7H-Pyrrolo[2,3-d]pyriMidine,2-chloro-;1H-Pyrrolo[2,3-d]pyrimidine, 2-chloro-
• CAS NO: 335654-06-3
• Molecular Formula: C₆H₄ClN₃
• Molecular Weight: 153.57
• Product Categories: Amines;Bases & Related Reagents;Intermediates;Nucleotides;Tyrosine Kinase Inhibitors;Heterocycle-Pyrimidine series
• Mol File: 335654-06-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 318.271 °C at 760 mmHg
• Flash Point: 146.285 °C
• Appearance: /
• Density: 1.61 g/cm³
• Refractive Index: 1.72
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 11.18±0.50(Predicted)
• CAS DataBase Reference: 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE(335654-06-3)
• EPA Substance Registry System: 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE(335654-06-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45-24/25
• RIDADR: UN2811
• Hazardous Substances Data: 335654-06-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 335654-06-3 differently. You can refer to the following data:
1. An intermediate pyrrolo-pyrimidine compound, 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine can be used in the preparation of tyrosine kinase inhibitors, particularly oral signal transducers and activators of transcription 6 (STAT6) inhibitors.
2. An intermediate pyrrolo-pyrimidine compound used in the preparation of tyrosine kinase inhibitors, particularly oral signal transducers and activators of transcription 6 (STAT6) inhibitors.

InChI:InChI=1/C6H4ClN3/c7-6-9-3-4-1-2-8-5(4)10-6/h1-3H,(H,8,9,10)

Upstream product

• 90213-66-4 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine 
• 335654-05-2 2-chloro-5-(2-ethoxyvinyl)pyrimidin-4-amine 

Downstream Products

• 863599-38-6 2-chloro-7-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine 
• 1180153-52-9 (4-Isopropoxy-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-2-yl)-amine 
• 1180134-30-8 2-chloro-7-(4-(methylsulfonyl)phenyl)-7H-pyrrolo[2,3-d]-pyrimidine 
• 1180153-48-3 2-chloro-7-(3,5-difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1060815-90-8 2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine 
• 1428444-23-8 N-(3-((2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)phenyl)ethenesulfonamide 
• 1428444-32-9 7-(3-aminobenzyl)-N-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 1428444-31-8 N-(1-methyl-1H-pyrazol-4-yl)-7-(3-nitrobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 1428444-25-0 N-(3-((2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)phenyl)acrylamide 
• 1428444-30-7 2-chloro-7-(3-nitrobenzyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1403894-25-6 2-chloro-7-(2-fluorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1403894-06-3 2-(4-(7-(2-fluorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-1H-pyrazol-1-yl)ethanol 
• 1060816-67-2 2-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine 
• 909562-68-1 2-chloro-7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]-pyrimidine 

Relevant articles and documents

Preparation method of 5-bromo-2-chloro-7H-pyrrolo [2, 3-d] pyrimidine

The invention discloses a preparation method of 5-bromo-2-chloro-7H-pyrrolo[2, 3-b] pyridine. According to the method, 2,4-chloro-7H-pyrrolo[2, 3-d] pyrimidine is used as a starting raw material, in the presence of zinc powder and acetic acid, selective d

Method for selective dehalogenation in pyrimidine fused ring

The invention discloses a method for selective dehalogenation in pyrimidine fused ring. Through heating reaction between zinc powder and acetic acid solution, selective dehalogenation is conducted on pyrimidine ring to maintain original substituents on pyrimidine ring and fused ring. The method comprises few operation steps with high yield, and is applicable to mass production.

COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS

The present application provides novel optionally substituted fused pyridine and pyrimidine bicyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating FAK and/or Src activity by administering a therapeutically effective amount of one or more of the compounds to a subject. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the FAK and/or Src pathway. Advantageously, these compounds perform as dual FAK and/or Src inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.